Molecular basis and cellular mechanisms of eosinophilic esophagitis for the clinical practice

Expert Review of Gastroenterology & Hepatology
Angel Arias, Alfredo Lucendo

Abstract

Eosinophilic esophagitis (EoE) is a chronic, allergen-driven inflammatory esophageal disease characterized by predominantly eosinophilic inflammation leading to esophageal dysfunction. Recent efforts to understand EoE have increased our knowledge of the disease. Areas covered: Multiple cells, molecules, and genes interplay with early life environmental factors in the pathophysiology of EoE to converge in the esophageal epithelium at the center of disease pathogenesis. Epithelial cells constitute a mayor cytokine source for TSLP and Calpain-14; an impaired epithelial barrier function allowing penetration of food and microbiota-derived antigens is involved in triggering and maintaining inflammation. Eosinophil and mast cell-derived products, including TGFβ, together with IL-1β and TNFα, promote epithelial mesenchymal transition in EoE, contributing to tissue remodeling by synthetizing and depositing extracellular matrix in subepithelial layers. This article aims to provide a state-of-the-art update on the pathophysiology of EoE applied to clinical practice, and latest research and developments with potential interest to improve the diagnosis and treatment of patients with EoE are revised. Expert commentary: Preliminary approaches...Continue Reading

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Citations

Dec 18, 2019·Expert Review of Clinical Immunology·Alfredo J Lucendo
Nov 26, 2019·Minerva gastroenterologica e dietologica·Alfredo J Lucendo, Javier Molina-Infante
Jul 3, 2020·Expert Review of Gastroenterology & Hepatology·Alfredo J Lucendo, Javier Molina-Infante
Jul 18, 2020·Alimentary Pharmacology & Therapeutics·Emilio J Laserna-MendietaUNKNOWN EUREOS EoE CONNECT Research group
May 31, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Alfredo J Lucendo, Piedad López-Sánchez
Aug 5, 2020·Expert Review of Gastroenterology & Hepatology·Ángel Arias, Alfredo J Lucendo
Jan 3, 2020·Abdominal Radiology·Patricia V HernandezJennifer L Horsley-Silva
Jan 24, 2021·Immunologic Research·Yueqi ChenFang Liu
Nov 16, 2019·Current Pediatric Reviews·Giorgio CostagliolaDiego Peroni
Oct 24, 2021·Gastroenterology·Tetsuo ShodaUNKNOWN Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) Investigators Group
Jan 25, 2022·Expert Opinion on Investigational Drugs·Sonsoles Tamarit-SebastianAlfredo J Lucendo

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