Molecular basis and current treatment for alcoholic liver disease.

International Journal of Environmental Research and Public Health
Alejandra Miranda-MendezJuan Armendariz-Borunda

Abstract

Alcohol use disorders and alcohol dependency affect millions of individuals worldwide. The impact of these facts lies in the elevated social and economic costs. Alcoholic liver disease is caused by acute and chronic exposure to ethanol which promotes oxidative stress and inflammatory response. Chronic consumption of ethanol implies liver steatosis, which is the first morphological change in the liver, followed by liver fibrosis and cirrhosis. This review comprises a broad approach of alcohol use disorders, and a more specific assessment of the pathophysiologic molecular basis, and genetics, as well as clinical presentation and current modalities of treatment for alcoholic liver disease.

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Methods Mentioned

BETA
biopsy
imaging techniques
pharmacotherapy

Software Mentioned

COMBINE
FibroTest
FibroScan

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