Molecular basis for damage recognition and verification by XPC-RAD23B and TFIIH in nucleotide excision repair

DNA Repair
Hong MuOrlando D Schärer

Abstract

Global genome nucleotide excision repair (GG-NER) is the main pathway for the removal of bulky lesions from DNA and is characterized by an extraordinarily wide substrate specificity. Remarkably, the efficiency of lesion removal varies dramatically and certain lesions escape repair altogether and are therefore associated with high levels of mutagenicity. Central to the multistep mechanism of damage recognition in NER is the sensing of lesion-induced thermodynamic and structural alterations of DNA by the XPC-RAD23B protein and the verification of the damage by the transcription/repair factor TFIIH. Additional factors contribute to the process: UV-DDB, for the recognition of certain UV-induced lesions in particular in the context of chromatin, while the XPA protein is believed to have a role in damage verification and NER complex assembly. Here we consider the molecular mechanisms that determine repair efficiency in GG-NER based on recent structural, computational, biochemical, cellular and single molecule studies of XPC-RAD23B and its yeast ortholog Rad4. We discuss how the actions of XPC-RAD23B are integrated with those of other NER proteins and, based on recent high-resolution structures of TFIIH, present a structural model of ...Continue Reading

References

Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M J Smerdon, M W Lieberman
Feb 10, 1995·The Journal of Biological Chemistry·D MuA Sancar
Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·M T HessH Naegeli
Jul 3, 1999·The Journal of Biological Chemistry·Y FujiwaraS Iwai
Feb 8, 2000·The Journal of Biological Chemistry·G S WinklerG Weeda
Aug 21, 2001·Molecular Cell·M VolkerL H Mullenders
Aug 29, 2003·The Journal of Biological Chemistry·Maureen E FitchJames M Ford
Oct 1, 2003·The EMBO Journal·Thilo RiedlJean-Marc Egly
Feb 26, 2004·The Journal of Biological Chemistry·Angels TapiasJean-Marc Egly
Aug 30, 2005·Chemistry & Biology·Tonko ButerinHanspeter Naegeli
Oct 4, 2005·Journal of Computational Chemistry·David A CaseRobert J Woods
Feb 9, 2006·Chemical Reviews·Ludovic C J Gillet, Orlando D Schärer
Feb 24, 2006·Nature Structural & Molecular Biology·Ulrike CamenischHanspeter Naegeli
Jul 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·Arthur P GrollmanBojan Jelaković
Sep 21, 2007·Nature·Jung-Hyun Min, Nikola P Pavletich
May 31, 2008·Cell·Huanting LiuMalcolm F White
Jun 27, 2008·PLoS Biology·Stefanie C WolskiCaroline Kisker
Jul 11, 2008·Molecular Cell·Frédéric CoinJean Marc Egly
Aug 7, 2008·Journal of Cell Science·Deborah HoogstratenAdriaan B Houtsmuller
Sep 24, 2008·Molecular and Cellular Biology·Bruno M Bernardes de JesusJean Marc Egly
Dec 27, 2008·Cell·Andrea ScrimaNicolas H Thomä
Mar 13, 2009·The EMBO Journal·Lidija StaresincicOrlando D Schärer
Jul 18, 2009·The EMBO Journal·Ulrike CamenischHanspeter Naegeli

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Citations

Jan 12, 2020·Nucleic Acids Research·Agnieszka M Topolska-WośWalter J Chazin
Feb 13, 2020·Nucleic Acids Research·Abhinandan PanigrahiMarimuthu Krishnan
Oct 4, 2020·Nucleic Acids Research·Namrata KumarBennett Van Houten
Mar 29, 2020·Biochemical Society Transactions·Chiara Vittoria ColomboMaria Pia Longhese
Nov 13, 2019·Parasites & Vectors·Maria Beatriz S MotaRafael D Mesquita
Apr 3, 2020·International Journal of Molecular Sciences·Lucia Borszéková PulzováMiroslav Chovanec
Feb 2, 2021·The Journal of Investigative Dermatology·Christian T Wong, Dennis H Oh
Mar 5, 2021·Nucleic Acids Research·Joseph TibbsMaria Spies
Aug 3, 2019·American Journal of Human Genetics·Vinod Tiwari, David M Wilson
Jun 9, 2021·Nature Communications·Trevor van EeuwenKenji Murakami
Jul 3, 2021·International Journal of Molecular Sciences·Yuliya KrasikovaOlga Lavrik
Nov 4, 2021·Cellular and Molecular Life Sciences : CMLS·Katja ApeltMartijn S Luijsterburg

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