PMID: 2494665Apr 1, 1989Paper

Molecular basis for expression of the A48 regulatory idiotope on antibodies encoded by immunoglobulin variable-region genes from various families

Proceedings of the National Academy of Sciences of the United States of America
H ZaghouaniC Bona

Abstract

The idiotype defined by the levan-specific BALB/c myeloma protein ABPC48 (A48) has previously been encountered only in antibodies the variable regions of which derive from the VHX24 and V kappa 10 gene families. We have demonstrated expression of the idiotope recognized by the monoclonal anti-A48 idiotype antibody IDA10 on five monoclonal antibodies from different mouse strains, with different specificities including foreign and self antigens and deriving their variable regions from families other than VHX24 and V kappa 10. We analyzed variable region protein structure (deduced from nucleotide sequences) and hydrophilicity profiles of idiotype+ and idiotype- antibodies. We identified four surface-exposed areas (one in the heavy chain and three in the light chain) that may contribute to expression of the idiotope defined by antibody IDA10.

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Citations

Jul 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·H ZaghouaniC Bona
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J TassignonK Meek
Sep 25, 1989·Nucleic Acids Research
May 1, 1991·The Journal of Clinical Investigation·A J Manheimer-LoryB A Diamond
Feb 13, 2016·Frontiers in Microbiology·Alena JandaArturo Casadevall
Jul 1, 1991·Clinical Immunology and Immunopathology·J M Greally
Aug 1, 1995·European Journal of Immunology·A Umar, P J Gearhart
Sep 1, 1991·European Journal of Immunology·T KoizumiR S Schwartz
Jan 1, 1989·International Reviews of Immunology·C Victor-Kobrin, C A Bona

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