Molecular basis for nonspecificity of nonsteroidal anti-inflammatory drugs (NSAIDs)

Drug Discovery Today
Avaneesh K DwivediNagendra Singh

Abstract

Inhibition of the production of inflammatory mediators by the action of nonsteroidal anti-inflammatory drugs (NSAIDs) is highly accredited to their recognition of cyclooxygenase enzymes. Along with inflammation relief, however, NSAIDs also cause adverse effects. Although NSAIDs strongly inhibit enzymes of the prostaglandin synthesis pathways, several other proteins also serve as fairly potent targets for these drugs. Based on their recognition pattern, these receptors are categorised as enzymes modifying NSAIDs, noncatalytic proteins binding to NSAIDs and enzymes with catalytic functions that are inhibited by NSAIDs. The extensive binding of NSAIDs is responsible for their limited in vivo efficacy as well as the large spectrum of their effects. The biochemical nature of drugs binding to multiple protein targets and its implications on physiology are discussed.

References

Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·L KaplanP Elsbach
Dec 1, 1976·The Journal of Allergy and Clinical Immunology·J R Vane
Mar 1, 1992·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J WatanabeS Kanamura
Jul 1, 1991·European Journal of Biochemistry·B DesfossesM Waks
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P WestermarkG G Cornwell
Feb 13, 1993·Biochimica Et Biophysica Acta·R ChatterjeeR K Banerjee
Aug 1, 1995·Protein Engineering·K N Degtyarenko
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·C J Hawkey
Feb 13, 1997·The New England Journal of Medicine·D R JacobsonJ N Buxbaum
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·T D WarnerJ R Vane
Jul 24, 2001·Clinical Cornerstone·G A Green
Aug 31, 2001·JAMA : the Journal of the American Medical Association·D MukherjeeE J Topol
Mar 6, 2002·Alimentary Pharmacology & Therapeutics·W A StackC J Hawkey
Mar 26, 2002·FEBS Letters·Lei Zeng, Ming Ming Zhou
Sep 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·N V ChandrasekharanDaniel L Simmons
Dec 14, 2002·Journal of the American College of Nutrition·Artemis P Simopoulos
Feb 5, 2003·Current Medical Research and Opinion·Stefania TacconelliPaola Patrignani
Aug 20, 2003·The Journal of Biological Chemistry·Scott W RowlinsonLawrence J Marnett
Dec 4, 2003·European Journal of Clinical Nutrition·F J TroostR-J M Brummer
Jan 27, 2004·Bioorganic & Medicinal Chemistry Letters·Kushol GuptaPatrick J Loll
Jun 8, 2004·The Journal of Biological Chemistry·Michael R WesterEric F Johnson
Sep 1, 1994·Acta Crystallographica. Section D, Biological Crystallography·UNKNOWN Collaborative Computational Project, Number 4
Dec 2, 2004·Acta Crystallographica. Section D, Biological Crystallography·Paul Emsley, Kevin Cowtan
Feb 15, 2005·Drug Discovery Today·Warren L DeLano
Sep 20, 2005·Journal of Molecular Biology·Jamie GhumanStephen Curry
Sep 27, 2005·Digestive Diseases and Sciences·Katya Gudis, Choitsu Sakamoto
Nov 23, 2005·Biochemistry·Ted R FossJeffery W Kelly
Dec 20, 2005·Cell·Michael Lehrke, Mitchell A Lazar
Jun 22, 2006·Journal of the National Cancer Institute·Maen AbdelrahimStephen Safe
Dec 7, 2007·Chemical Research in Toxicology·F Peter Guengerich
Dec 9, 2008·Antioxidants & Redox Signaling·Milton HamblinY Eugene Chen
May 9, 2009·Molecular Endocrinology·Neil J McKennaBert W O'Malley
Jul 28, 2009·Gastrointestinal Endoscopy·Denis M McCarthy
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gilad RimonWilliam L Smith

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Citations

Apr 10, 2016·Archives of Biochemistry and Biophysics·Vikram JoshiBannikuppe Sannanaik Vishwanath
Sep 1, 2016·Biochemical and Biophysical Research Communications·Bo-Young KimKoanhoi Kim
Oct 14, 2016·Clinical and Translational Science·T LiuR B Altman
Nov 2, 2016·The Cochrane Database of Systematic Reviews·Eva Rasmussen-BarrMaria M Wertli
Jul 13, 2017·The Cochrane Database of Systematic Reviews·Sheena DerryBee Wee
Jan 10, 2018·Frontiers in Pharmacology·Lucía Paniagua-HerranzEsmerilda G Delicado
Jul 25, 2020·Drug Research·Hugo F MirandaJuan Carlos Prieto
Apr 12, 2017·Spine·Eva Rasmussen-BarrMaria M Wertli
Sep 3, 2020·Indian Journal of Palliative Care·Raghavendra RamanjuluDipasri Bhattacharya
Feb 16, 2019·Drug Development Research·Claudio Gonzalez VargasJuan Carlos Prieto
Dec 15, 2020·Biotechnology and Applied Biochemistry·Menglan Wang, Baskaran Thyagarajan
May 9, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Alexandru SavaLenuţa Profire

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