Molecular Basis for Resistance Against Phosphonate Antibiotics and Herbicides

MedChemComm
Jonathan R ChekanSatish K Nair

Abstract

Research in recent years have illuminated data on the mechanisms and targets of phosphonic acid antibiotics and herbicides, including fosfomycin, glyphosate, fosmidomycin and FR900098. Here we review the current state of knowledge of the structural and biochemical characterization of resistance mechanisms against these bioactive natural products. Advances in the understanding of these resistance determinants have spurred knowledge-based campaigns aimed towards the design of derivatives that retain biological activity but are less prone to tolerance.

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Citations

Nov 26, 2015·Molecular Pharmaceutics·Long Binh Vong, Yukio Nagasaki
Dec 16, 2016·ACS Chemical Biology·Philip OlivaresSatish K Nair
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Apr 21, 2021·Environmental Microbiology·Robert HertelFabian M Commichau

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