Molecular Basis for Stellatic Acid Biosynthesis: A Genome Mining Approach for Discovery of Sesterterpene Synthases

Organic Letters
Yudai MatsudaIkuro Abe

Abstract

The search for a new sesterterpene synthase in the genome of Emericella variecolor, which reportedly produces diverse sesterterpenoids, is described. One gene product (a chimeric protein with prenyltransferase and terpene cyclase domains) led to the synthesis of a novel tricyclic sesterterpene, stellata-2,6,19-triene (1), from DMAPP and IPP, and the hydrocarbon was further transformed into stellatic acid (2) by cytochrome P450 monooxygenase encoded by the gene adjacent to the sesterterpene synthase gene.

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Citations

Jul 23, 2016·Journal of the American Chemical Society·Masahiro OkadaIkuro Abe
Apr 1, 2017·Biochemistry·Travis A PembertonDavid W Christianson
Feb 17, 2017·Natural Product Reports·Jeroen S Dickschat
Jun 9, 2016·Natural Product Reports·Nadine ZiemertTilmann Weber
Jul 4, 2017·Chemistry : a European Journal·Takaaki MitsuhashiJeroen S Dickschat
Apr 21, 2018·Chembiochem : a European Journal of Chemical Biology·Takaaki Mitsuhashi, Ikuro Abe
Sep 5, 2017·Chembiochem : a European Journal of Chemical Biology·Takaaki MitsuhashiIkuro Abe
Dec 15, 2018·Organic & Biomolecular Chemistry·Jia-Hua HuangDan Hu
Nov 19, 2019·Bioscience, Biotechnology, and Biochemistry·Hideaki Oikawa
Sep 3, 2019·Chembiochem : a European Journal of Chemical Biology·Jan RinkelJeroen S Dickschat
Apr 21, 2020·Critical Reviews in Biotechnology·Leixia ChuJiangtao Gao

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