Molecular basis for the ATPase activity of CFTR

Archives of Biochemistry and Biophysics
Joanne C CheungChristine E Bear

Abstract

CFTR is a member of the ABC (ATP binding cassette) superfamily of transporters. It is a multidomain membrane protein, which utilizes ATP to regulate the flux of its substrate through the membrane. CFTR is distinct in that it functions as a channel and it possesses a unique regulatory R domain. There has been significant progress in understanding the molecular basis for CFTR activity as an ATPase. The dimeric complex of NBD structures seen in prokaryotic ABC transporters, together with the structure of an isolated CF-NBD1, provide a unifying molecular template to model the structural basis for the ATPase activity of CFTR. The dynamic nature of the interaction between the NBDs and the R domain has been revealed in NMR studies. On the other hand, understanding the mechanisms mediating the transmission of information from the cytosolic domains to the membrane and the channel gate of CFTR remains a central challenge.

References

Mar 24, 2006·Nature·David C GadsbyLászló Csanády

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Citations

Jan 30, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Monika KlochKrzysztof Dołowy
Feb 19, 2011·American Journal of Respiratory and Critical Care Medicine·Malena Cohen-CymberknohEitan Kerem
May 21, 2009·Biological Chemistry·Ute A Hellmich, Clemens Glaubitz
Sep 17, 2014·The Journal of General Physiology·Wen-Ying LinTzyh-Chang Hwang
Feb 25, 2015·Journal of Molecular Recognition : JMR·Elena K SchneiderTony Velkov
May 30, 2009·Chemistry & Biology·Patrick Kim ChiawChristine E Bear
Apr 3, 2013·Jornal de pediatria·Daniela M BernardiValdemiro C Sgarbieri
Nov 22, 2011·Biochimica Et Biophysica Acta·Nicola J Harris, Paula J Booth
Jan 1, 2011·Cancers·Angel L OrtegaJose M Estrela
May 27, 2010·Molecular Pharmacology·Patrick Kim ChiawChristine E Bear
Jan 27, 2021·International Journal of Clinical Practice·Fernanda Maria VendrusculoMárcio Vinícius Fagundes Donadio
Nov 17, 2020·Frontiers in Bioengineering and Biotechnology·Martina OrianoPaola Petrini

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