PMID: 9188580Jul 1, 1997Paper

Molecular basis for the differential subcellular localization of the 38- and 39-kilodalton structural proteins of Borna disease virus

Journal of Virology
J M Pyper, A E Gartner

Abstract

Borna disease virus (BDV) is a nonsegmented negative-strand (NNS) RNA virus that is unusual because it replicates in the nucleus. The most abundant viral protein in infected cells is a 38/39-kDa doublet that is presumed to represent the nucleocapsid. Infectious particles also contain high levels of this protein, accounting for at least 50% of the viral proteins. The two forms of the protein differ by an additional 13 amino acids that are present at the amino terminus of the 39-kDa form and missing from the 38-kDa form. To examine whether this difference in amino acid content affects the localization of this protein in cells, the 39- and 38-kDa proteins were expressed in transfected cells. The 39-kDa form was concentrated in the nucleus, whereas the 38-kDa form was found in both the nucleus and cytoplasm. Inspection of the extra 13 amino acids present in the 39-kDa form revealed a sequence (Pro-Lys-Arg-Arg) that is very similar to the nuclear localization signals (in both sequence homology and amino-terminal location) of the VP1 proteins of simian virus 40 and polyomavirus. Primer extension analysis of total RNA from infected cells suggests that there are two mRNA species encoding the two forms of the nucleocapsid protein. In in...Continue Reading

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Citations

Jul 23, 2002·Journal of Virology·Michelle Portlance Walker, W Ian Lipkin
Oct 24, 2003·The Journal of General Virology·Mar PerezJuan Carlos de la Torre
Sep 12, 2006·Nature Reviews. Microbiology·Juan C de la Torre
Mar 6, 2010·Emerging Infectious Diseases·Patricia GrayIan Tizard
Aug 24, 2013·Viruses·Tomoyuki Honda, Keizo Tomonaga
Jan 1, 2012·Uirusu·Keizo Tomonaga
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Jun 21, 2002·The Journal of General Virology·María Eugenia Sánchez de la TorreMaría Laura García
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Dec 14, 2018·Journal of Virology·Shohei KojimaKeizo Tomonaga
Jun 16, 2021·Archives of Virology·Florian Pfaff, Dennis Rubbenstroth
Mar 10, 2001·Reviews in Medical Virology·I Jordan, W I Lipkin

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