PMID: 11927274Apr 3, 2002Paper

Molecular basis of cholesterol homeostasis: lessons from Tangier disease and ABCA1

Trends in Molecular Medicine
J F Oram

Abstract

High-density lipoproteins (HDLs) play a role in transporting cholesterol from peripheral tissues to the liver for elimination from the body. Two hallmarks of cardiovascular disease are the presence of sterol-laden macrophages in the artery wall and reduced plasma HDL levels. A cell-membrane protein called ABCA1 mediates the secretion of excess cholesterol from cells into the HDL metabolic pathway. Mutations in ABCA1 cause Tangier disease, a severe HDL deficiency syndrome characterized by accumulation of cholesterol in tissue macrophages and prevalent atherosclerosis. Because of its ability to deplete macrophages of cholesterol and to raise plasma HDL levels, ABCA1 has become a promising therapeutic target for preventing cardiovascular disease.

References

Oct 26, 1978·The New England Journal of Medicine·E J SchaeferH B Brewer
Apr 4, 1986·Science·M S Brown, J L Goldstein
Jul 1, 1995·The Journal of Clinical Investigation·G A FrancisJ F Oram
Oct 1, 1994·The Journal of Clinical Investigation·A J MendezJ F Oram
Jan 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·J R Guyton, K F Klemp
Oct 6, 1998·Annual Review of Biochemistry·R G Anderson
Jan 6, 1999·Proceedings of the National Academy of Sciences of the United States of America·B A JanowskiD J Mangelsdorf
Apr 27, 1999·Biochimica Et Biophysica Acta·S W SakrG H Rothblat
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·M S Brown, J L Goldstein
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y Takahashi, J D Smith
Dec 22, 1999·Current Opinion in Biotechnology·J J Repa, D J Mangelsdorf
Feb 23, 2000·The Journal of Clinical Investigation·Y Luo, A R Tall
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·J McNeishO L Francone
Jun 20, 2000·The Journal of Biological Chemistry·P CostetA R Tall
Jul 14, 2000·The Journal of Biological Chemistry·A E BortnickO L Francone
Aug 5, 2000·Biochemical and Biophysical Research Communications·K SchwartzD P Wade
Sep 27, 2000·Biochimica Et Biophysica Acta·Y TakahashiJ D Smith
Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·A VenkateswaranP Tontonoz
Nov 23, 2000·Genes & Development·J R SchultzB Shan
Jan 10, 2001·Proceedings of the National Academy of Sciences of the United States of America·B A LaffitteP Tontonoz
Jan 21, 2001·The Journal of Biological Chemistry·O ChambenoitG Chimini
Feb 13, 2001·Biochemical and Biophysical Research Communications·A T RemaleyH B Brewer

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Citations

Dec 10, 2002·Biochemical and Biophysical Research Communications·Elda FavariLaura Calabresi
Apr 23, 2003·Molecular Genetics and Metabolism·Maxime DenisJacques Genest
Sep 16, 2003·Plant Physiology·Yong-Qing ZhuXiao-Ya Chen
Nov 26, 2009·Molecular and Cellular Biology·Mattéa BujoldKirst King-Jones
Jul 12, 2005·The Journal of Clinical Investigation·Masashi AkiyamaHiroshi Shimizu
Dec 23, 2009·BMC Cell Biology·Ildikó KaszaLászló Homolya
Jul 10, 2012·Lipids in Health and Disease·Vana KolovouConstantinos A Demopoulos
Apr 14, 2007·Molecular Neurodegeneration·Suzanne E WahrleDavid M Holtzman
Sep 4, 2014·Annual Review of Genomics and Human Genetics·Frances M PlattForbes D Porter
Sep 25, 2010·Hematology·Vassiliki Saloura, Petros D Grivas
Mar 27, 2015·BioFactors·Fabiana H RachedAnatol Kontush
Feb 3, 2005·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Matthew Z DieterCurtis D Klaassen
Jun 16, 2015·The Journal of Clinical Investigation·Aaron M FondKodi S Ravichandran
Jun 6, 2003·Biochimica Et Biophysica Acta·Adriana Parodi-TaliceSantiago Castanys
Mar 23, 2004·Biochemical and Biophysical Research Communications·Hirohito SoneNobuhiro Yamada
Jul 28, 2016·Stem Cells Translational Medicine·Chengcheng CuiJieli Chen
Jun 11, 2008·Journal of Lipid Research·Vijay PaulChristiane Albrecht
Mar 18, 2005·Journal of Lipid Research·Jonathan M CoutinhoMichael R Hayden
Feb 7, 2018·Brain Sciences·Tomonori AikawaTakahisa Kanekiyo
May 28, 2004·The Journal of Biological Chemistry·Jerzy-Roch NoferBeate E Kehrel
Oct 19, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Martin H KangMichael R Hayden
Aug 9, 2007·Bioorganicheskaia khimiia·A V AntonchikV A Khripach
Apr 13, 2005·The Journal of Biological Chemistry·Tanya C McCarthyChristopher J Sinal
Jul 10, 2002·The Journal of Biological Chemistry·Torsten PlōschFolkert Kuipers
Jul 26, 2017·Journal of Cardiovascular and Thoracic Research·Yasin AhmadiHassan Argani
Feb 23, 2021·ACS Pharmacology & Translational Science·Manel Ben AissaGregory R J Thatcher
Nov 13, 2004·Journal of Cell Science·Anna MarchettiPierre Cosson
May 8, 2021·Oxidative Medicine and Cellular Longevity·Xiao-Hua YuKun Ren
Nov 18, 2005·The International Journal of Biochemistry & Cell Biology·Adriana P MachadoMarisa Passarelli
Oct 17, 2008·Atherosclerosis·Laura CalabresiGuido Franceschini

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