Molecular basis of cleft palates in mice

World Journal of Biological Chemistry
Noriko FunatoHiromi Yanagisawa

Abstract

Cleft palate, including complete or incomplete cleft palates, soft palate clefts, and submucosal cleft palates, is the most frequent congenital craniofacial anomaly in humans. Multifactorial conditions, including genetic and environmental factors, induce the formation of cleft palates. The process of palatogenesis is temporospatially regulated by transcription factors, growth factors, extracellular matrix proteins, and membranous molecules; a single ablation of these molecules can result in a cleft palate in vivo. Studies on knockout mice were reviewed in order to identify genetic errors that lead to cleft palates. In this review, we systematically describe these mutant mice and discuss the molecular mechanisms of palatogenesis.

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Citations

Mar 15, 2016·Toxicology and Applied Pharmacology·Zhan GaoZengli Yu
Jan 21, 2017·International Journal of Oral Science·Noriko Funato, Masataka Nakamura
Jul 22, 2017·Journal of Dental Research·X FuY Lan
Aug 17, 2017·Journal of Dental Research·S JiaR N D'Souza
Jan 13, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Glenda ComaiAndreas Schedl
Jul 2, 2020·Journal of Dental Research·J D OliverR N D'Souza
May 12, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Shihai JiaRena N D'Souza
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Katiúcia Batista Silva PaivaAriadne Letra
Sep 3, 2020·Tissue Engineering. Part B, Reviews·Jeremie D OliverRena N D'Souza
Nov 20, 2015·The Journal of Biological Chemistry·Veronika Anita DeákEnno Klussmann
Jan 24, 2020·World Journal of Clinical Cases·Jin-Feng Zhang, Wen-Bin Zhang
Jan 17, 2020·Human Molecular Genetics·Everett G HallIrfan Saadi
Mar 15, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Brian J PaulMartine Dunnwald
Nov 18, 2021·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Aline Cristina da Silva TrevizanLucimara Teixeira das Neves

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