Molecular basis of pluripotency

Human Molecular Genetics
Lingyi Chen, George Q Daley

Abstract

Embryonic stem (ES) cells are pluripotent and capable of self-renewal, thus holding promise for regenerative medicine. Recent studies have begun to provide insights into the molecular mechanisms underlying pluripotency and self-renewal. In this article, we discuss the roles of transcriptional regulation, epigenetic regulation and miRNAs in the maintenance of pluripotency and the differentiation of ES cells.

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Related Concepts

Embryo
Transcriptional Regulation
Regenerative Medicine
Pluripotent Stem Cells
RNA, Small Temporal
Cell Differentiation Process
Study of Epigenetics
Epigenesis, Genetic
Embryonic Stem Cells
Transcription Factor

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