Molecular basis of predisposition to develop type 1 diabetes mellitus in North Indians

Tissue Antigens
R RaniR Goswami

Abstract

Type 1 diabetes (T1D) mellitus is a multifactorial autoimmune disease where more than 90% of insulin-producing pancreatic beta cells are destroyed before the clinical manifestations, warranting a need to identify the children predisposed to get the disease. Of the 20 genomic intervals implicated for the risk to develop T1D, the major histocompatibility complex (MHC) region on chromosome 6p21.31 (IDDM1) has been the major contributor, followed by 5' regulatory region of the insulin (INS) gene on chromosome 11p15.5 (IDDM2). MHC has a role in antigen presentation and IDDM2 has been shown to have a role in transcription of insulin in the thymus. Hence, alleles of human leukocyte antigen (HLA)-DRB1, DQB1, and insulin-linked variable number of tandem repeats (INS-VNTR) were studied in 110 T1D patients and 112 healthy controls using polymerase chain reaction and hybridization with sequence-specific oligonucleotide probes (PCR-SSOP) and PCR restriction fragment length polymorphism (PCR-RFLP), respectively. HLA-DRB1*0301 was significantly increased in the T1D patients along with associated DQB1*0201 followed by DRB1*0401 and DRB1*0405. DRB1*0701 was observed to be the most protective allele followed by DRB1*0403 and DRB1*0404. Although ...Continue Reading

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Citations

Mar 29, 2012·Current Diabetes Reports·Eesh Bhatia
Nov 6, 2012·Genetic Testing and Molecular Biomarkers·Oindrila RahaVadlamudi Raghavendra Rao
Feb 10, 2010·International Journal of Diabetes in Developing Countries·Oindrila RahaV R Rao
May 19, 2010·Biomarkers in Medicine·Neeraj KumarNarinder Mehra
Nov 1, 2006·Expert Review of Clinical Immunology·Narinder Mehra, Gurvinder Kaur
Aug 13, 2011·The Journal of Investigative Dermatology·Archana SinghRajni Rani
Sep 12, 2007·International Journal of Immunogenetics·G N MalavigeG S Ogg
Mar 10, 2018·PloS One·Abdelhafidh HajjejSlama Hmida
Oct 20, 2018·Biomédica : revista del Instituto Nacional de Salud·Diana Clobeth SarrazolaNicolás Pineda-Trujillo
Jan 8, 2019·Journal of Diabetes·Neeraj KumarShekhar C Neolia
Apr 17, 2020·International Journal of Rheumatic Diseases·Jagdeep SinghRanjana Walker Minz
Jun 23, 2012·The Journal of Clinical Endocrinology and Metabolism·Ravinder GoswamiRajni Rani

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