PMID: 9168482Mar 1, 1997Paper

Molecular basis of the activity of the dopamine synapse in the mechanisms of learning and amnesia

Neuroscience and Behavioral Physiology
E K PodgornayaO V Polyakov

Abstract

The neurochemical correlates of dopamine synapse activity were studied during the retrieval of memory traces and in the absence of retrieval ("psychogenic" amnesia). The physiochemical parameters of D2 receptor function, the synaptic membrane, and the catechol content were assessed in various regions of the brain (striatum, neostriatum, hypothalamus, amygdala, frontal cortex, hippocampus, nucleus accumbens, and nuclei A9 and A10) in intact, trained, and amnesiac rats. It was demonstrated that disturbances in memory trace retrieval were associated with decreased activation of synaptic dopamine receptors and alterations in the dopamine transformation pathway in the rat brain.

References

Apr 1, 1985·Medicinal Research Reviews·C Kaiser, T Jain
Aug 1, 1967·Psychological Reports·M E Jarvik, R Kopp
Jan 1, 1984·Journal of Neuroscience Research·K Moroi, L L Hsu
Jan 1, 1993·Annual Review of Pharmacology and Toxicology·O CivelliD K Grandy

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Citations

Nov 25, 2004·Endocrine Reviews·Roy G SmithYuxiang Sun

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