Molecular basis of the delayed rectifier current I(ks)in heart

Journal of Molecular and Cellular Cardiology
J KurokawaRobert S Kass

Abstract

J. Kurokawa, H. Abriel and R. S. Kass. Molecular Basis of the Delayed Rectifier Current I(Ks)in Heart. Journal of Molecular and Cellular Cardiology (2001) 33, 873-882. Electrical activity underlies the control of the frequency, strength, and duration of contraction of the heart. During the cardiac cycle, a regular rhythmic pattern must be established in time-dependent changes in ionic conductances in order to ensure events that underlie normal cardiac function. This pattern must be tightly regulated by sympathetic nervous activity to ensure a physiologically relevant relationship between diastolic filling and ejection times with variable heart rate. The duration of the ventricular action potential is controlled in part by a slowly activated potassium channel current, I(Ks). The molecular identity of the subunits that comprise the channels conducting this current is important, not only for understanding the fundamental mechanisms that control electrical activity in healthy individuals, but also for understanding the molecular basis of at least one inherited human disease, LQTS-1. This brief review summarizes key points of information regarding the molecular determinants of the activity of these channels, their relationship to hu...Continue Reading

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Citations

Feb 15, 2008·Naunyn-Schmiedeberg's Archives of Pharmacology·Laszlo KölesPeter Illes
Dec 20, 2003·Progress in Cardiovascular Diseases·Ian W GlaaserColleen E Clancy
Oct 2, 2012·Genetic Testing and Molecular Biomarkers·Juan YaoBang-Dang Chen
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Oct 21, 2016·Journal of Arrhythmia·Jie WuMinoru Horie
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Dec 6, 2005·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Junko Kurokawa, Tetsushi Furukawa
Jun 1, 2005·Journal of Neuroscience Methods·Heung-Youp LeeAlan M Brichta

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