PMID: 15224708Jul 1, 2004Paper

Molecular biology and ontogeny of glutamate receptors in the mammalian central nervous system

Journal of Child Neurology
Timothy A SimeoneJong M Rho

Abstract

Glutamate is the principal excitatory neurotransmitter in the mammalian central nervous system. After release from presynaptic terminals, glutamate binds to both ionotropic and metabotropic receptors to mediate fast, slow, and persistent effects on synaptic transmission and integrity. There are three types of ionotropic glutamate receptors. N-Methyl-D-aspartate (NMDA), alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionic acid (AMPA), and kainate receptors are principally activated by the agonist bearing its name and are permeable to cationic flux; hence, their activation results in membrane depolarization. All ionotropic glutamate receptors are believed to be composed of four distinct subunits, each of which is topologically arranged with three transmembrane-spanning and one pore-lining (hairpin loop) domain. In contrast, metabotropic glutamate receptors are G protein (guanine nucleotide-binding protein) -coupled receptors linked to second-messenger systems. Group I metabotropic glutamate receptors are linked to phospholipase C, which results in phosphoinositide hydrolysis and release of calcium from intracellular stores. Group II and group III metabotropic glutamate receptors are negatively linked to adenylate cyclase, which c...Continue Reading

References

Jan 1, 1992·Neuron·Y TanabeS Nakanishi
Sep 14, 1992·Neuroscience Letters·D E Pellegrini-GiampietroR S Zukin
Jun 30, 1992·Biochemical and Biophysical Research Communications·H SugiharaS Nakanishi
Apr 15, 1992·The Journal of Comparative Neurology·R S Petralia, R J Wenthold
Jul 2, 1992·Nature·T KutsuwadaM Arakawa
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·N NakanishiN A Shneider
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D E Pellegrini-GiampietroW A Pulsinelli
Aug 19, 1991·Brain Research. Developmental Brain Research·M A SortinoP L Canonico
Feb 1, 1991·Journal of Neurophysiology·R A DeiszW Zieglgänsberger
Nov 7, 1991·Nature·K MoriyoshiS Nakanishi
May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·D E Pellegrini-GiampietroR S Zukin
Feb 22, 1991·Brain Research. Developmental Brain Research·G D Mower
Jan 1, 1990·Brain Research. Developmental Brain Research·E PalmerC W Cotman
Jan 1, 1990·Brain Research. Brain Research Reviews·J W McDonald, M V Johnston
Aug 3, 1990·Science·K KeinänenP H Seeburg
Jul 1, 1990·Pediatric Neurology·H Hattori, C G Wasterlain
May 1, 1989·Brain Research. Developmental Brain Research·S M DudekM F Bear
Apr 24, 1989·Neuroscience Letters·A RepresaY Ben-Ari
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F NicolettiE Costa
Nov 22, 1988·Neuroscience Letters·Y Ben-AriK Krnjevic

❮ Previous
Next ❯

Citations

Nov 3, 2011·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Botros B Kostandy
Jun 6, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·John B AmmoriMichael W Mulholland
Sep 14, 2010·Brain : a Journal of Neurology·Manju A KurianEamonn R Maher
Aug 25, 2001·Annual Review of Neuroscience·D S Rice, T Curran
Feb 11, 2014·Toxicon : Official Journal of the International Society on Toxinology·Randall J PlattBaldomero M Olivera
Nov 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ye WuTao Wang
Jan 1, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Palaniswamy RamaswamyNandakumar Dalavaikodihalli Nanjaiah
Jun 15, 2014·Trends in Neurosciences·Steve VucicMatthew C Kiernan
Mar 17, 2009·European Journal of Pharmacology·Bahareh Tavakoli-FarMassoud Mahmoudian
May 12, 2009·Behavioural Brain Research·Nina HsuMarcos G Frank
Jan 25, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ibolya E AndrásMichal Toborek
May 28, 2010·The Journal of Investigative Dermatology·Maithao N LeJames S Goydos
Dec 5, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C Beas-ZárateD Ortuño-Sahagún
Dec 2, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Yoshihisa WatanabeMasato Maekawa
Jul 31, 2004·Epilepsia·Jong M Rho
Nov 8, 2005·Journal of Neurochemistry·Alexander A BoldyrevPeter Johnson
May 19, 2009·American Journal of Medical Genetics. Part a·C BonnetP Jonveaux
Oct 11, 2007·Brain Pathology·Jia NewcombeTerence Smith
Oct 31, 2007·Pediatric Pulmonology·Rosemary T NettletonGeorge D Olsen
Aug 12, 2006·Stem Cells·Philippe TropelFrançois Berger
Jan 5, 2011·The European Journal of Neuroscience·Jocelyn M Richard, Kent C Berridge
Oct 16, 2010·American Journal of Medical Genetics. Part a·Richard J SchroerCharles E Schwartz
Jan 2, 2010·Brain Research·Silvia Josefina López-PérezAlberto Morales-Villagrán
May 6, 2006·European Journal of Medicinal Chemistry·Matthias LudwigKlaus T Wanner
May 18, 2005·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Selma DüzenliAkçahan Gepdiremen
Dec 25, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Steve VucicMatthew C Kiernan
Oct 28, 2016·Nature Reviews. Neurology·Nimeshan GeevasingaSteve Vucic
Oct 4, 2011·Multiple Sclerosis : Clinical and Laboratory Research·Steve VucicMatthew C Kiernan
Aug 15, 2009·Journal of Child Neurology·Mary L Zupanc
Nov 28, 2017·European Journal of Nuclear Medicine and Molecular Imaging·Geoffrey WarnockSimon M Ametamey
Oct 1, 2019·Physiology International·D N NandakumarK Goswami
Feb 18, 2017·Oncotarget·Mery Stefani Leivas PereiraDiogo Losch de Oliveira
Dec 19, 2016·Reviews in the Neurosciences·Seyed Amir Miratashi YazdiSeyed Masoud Miratashi Yazdi
Jan 11, 2020·Frontiers in Neuroanatomy·Sabrina BehuetKatrin Amunts
Feb 11, 2020·Fluids and Barriers of the CNS·Lilla BarnaMária A Deli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Current Opinion in Neurobiology
Stuart G Cull-CandyM Farrant
Brain Research. Developmental Brain Research
Laura M RitterJames H Meador-Woodruff
Science's STKE : Signal Transduction Knowledge Environment
Stuart G Cull-Candy, Daniel N Leszkiewicz
© 2022 Meta ULC. All rights reserved