Molecular biology in prostate cancer.

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
José Ramón Cansino Alcaide, Luis Martínez-Piñeiro

Abstract

Genes involved in cancer generation are usually tumor suppressors and oncogenes. Progressive genetic alterations in these genes are involved in the mechanisms of tumorigenesis. In prostate cancer, additionally several chromosomal loci that should harbor mutated genes have been proposed. Some genes have been found altered in prostate cancer, such as PTEN, TP53, AR, RNASEL (HPC1), ELAC2 (HPC2), CDKN2A and MSR1 and those can be natural targets for new strategies of treatment. Besides, gene therapy has been suggested to be suitable for prostate cancer treatment. This approach includes ex vivo corrective therapy, suicide, and antisense therapy.

References

Aug 17, 1989·The New England Journal of Medicine·E D CrawfordP J Goodman
Nov 24, 1999·Genes, Chromosomes & Cancer·R E ReiterR B Jenkins
May 1, 2001·Annals of Medicine·J P Elo, T Visakorpi
Aug 24, 2001·Nature·S M DhanasekaranA M Chinnaiyan
Oct 31, 2001·The American Journal of Surgical Pathology·Z JiangG R Fanger
Dec 26, 2001·The American Journal of Pathology·O SaramäkiT Visakorpi
Apr 3, 2002·JAMA : the Journal of the American Medical Association·Mark A RubinArul M Chinnaiyan
May 11, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kati PorkkaTapio Visakorpi

❮ Previous
Next ❯

Citations

Oct 15, 2011·The Journal of Biological Chemistry·Shao-An WangJan-Jong Hung
Sep 6, 2007·The Journal of Clinical Investigation·Russel S TaichmanKenneth J Pienta
Sep 2, 2010·PloS One·Regina Berretta, Pablo Moscato
Jan 24, 2008·The Prostate·Kenneth J PientaRobert L Vessella
Dec 23, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Erick Sierra DíazMaría Cristina Morán Moguel
Dec 4, 2009·Expert Opinion on Pharmacotherapy·Suwicha Limvorasak, Edwin M Posadas
Jan 6, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A ValentinoC Rolfo

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.