PMID: 11345196May 10, 2001Paper

Molecular biology of chronic myeloid leukemia

International Journal of Hematology
Yoshiro Maru

Abstract

Multistep carcinogenesis is exemplified by chronic myeloid leukemia with clinical manifestation consisting of a chronic phase and blast crisis. Pathological generation of BCR-ABL (breakpoint cluster region-Abelson) results in growth promotion, differentiation, resistance to apoptosis, and defect in DNA repair in targeted blood cells. Domains in BCR and ABL sequences work in concert to elicit a variety of leukemogenic signals including Ras, STAT5 (signal transducer and activator of transcription-5), Myc, cyclin D1, P13 (phosphatidylinositol 3-kinase), RIN1 (Ras interaction/interference), and activation of actin cytoskeleton. However, the mechanism of differentiation of transformed cells is poorly understood. A mutator phenotype of BCR-ABL could explain the transformation to blast crisis. The aim of this review is to integrate molecular and biological information on BCR, ABL, and BCR-ABL and to focus on how signaling from those molecules mirrors the biological phenotypes of chronic myeloid leukemia.

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Citations

Jun 4, 2002·International Journal of Hematology·Shin FujisawaYoshiaki Ishigatsubo
Dec 23, 2011·International Journal of Hematology·Noriko DokiToshio Kitamura
May 4, 2004·Leukemia Research·Takeshi KawanoHisashi Yamada
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Jul 2, 2003·Seminars in Oncology Nursing·Hollie Devine, Elaine DeMeyer
Jan 2, 2014·Journal of Chemical Information and Modeling·Ashini BoliaS Banu Ozkan
Nov 2, 2002·The EMBO Journal·Agata KlejmanTomasz Skorski
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Nov 26, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Yoshiro Maru
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Sep 23, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stephane WongOwen N Witte
Dec 23, 2008·Cancer Genetics and Cytogenetics·Tae Sung ParkJong Rak Choi
May 29, 2012·Cancer Science·Yoshiro Maru
Oct 19, 2010·The American Journal of Pathology·Kevin J JohnsonHallgeir Rui
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Jan 15, 2010·Blood·Alexey PalamarchukYuri Pekarsky
Sep 13, 2001·The Journal of Biological Chemistry·M P MartelliB E Bierer

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