PMID: 8594206Oct 1, 1995Paper

Molecular biology of CNS injury

Journal of Neurotrauma
Alexander Yakovlev, A I Faden

Abstract

Traumatic or ischemic injuries to the central nervous system (CNS) initiate reactive biochemical changes, some of which are autodestructive and others neuroprotective. Identification of these endogenous factors and their regulation will help to clarify mechanisms of secondary tissue damage and may lead to novel therapies. Recently developed molecular approaches offer opportunities for identifying genes involved in these reactive processes. Three types of molecular strategies are reviewed and examples are provided to demonstrate how each may be applied to elucidate basic mechanisms underlying posttraumatic or postischemic death.

References

Mar 1, 1992·Trends in Neurosciences·R Dubner, M A Ruda
Oct 8, 1992·Nature·R P BissonnetteD R Green
Apr 3, 1992·Cell·G I EvanD C Hancock
Jan 1, 1990·Progress in Brain Research·P F WorleyJ M Baraban
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·B HengererH Thoenen
Jan 1, 1990·Advances in Cancer Research·R J Distel, B M Spiegelman
Jan 1, 1990·Annals of Neurology·S S PanterA I Faden
Jan 1, 1988·Annual Review of Neuroscience·J G Sutcliffe
Dec 1, 1987·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T Curran, J I Morgan
Aug 25, 1983·Nucleic Acids Research·R J Milner, J G Sutcliffe
May 28, 1993·Annals of the New York Academy of Sciences·W H Lee, C Bondy
Jul 1, 1993·The American Journal of Surgical Pathology·G J NuovoB Lane
Jul 1, 1993·Trends in Neurosciences·R L Neve
Aug 1, 1994·Neurochemical Research·H BabaW B Macklin
Jan 1, 1994·Brain Pathology·P H Chan
Mar 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T Neumann-HaefelinK A Hossmann

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Citations

Mar 3, 1998·Journal of Molecular Neuroscience : MN·N Y HuangP Skolnick
Nov 17, 2004·Neurotoxicity Research·Kenneth I StraussRamesh Raghupathi
Nov 28, 2001·Journal of Neurotrauma·M Sasaki, L Dunn
Jun 14, 2003·Journal of Neurotrauma·Ramesh RaghupathiTracy K McIntosh
Jul 16, 2004·Journal of Neurotrauma·Christine BrabeckJan M Schwab
Feb 25, 1998·Journal of Neurotrauma·A I FadenA G Mukhin
Nov 14, 1998·Journal of Neurotrauma·M J WhalenP D Adelson
Jun 16, 1999·Journal of Neurotrauma·L FanA I Faden
May 28, 2009·Journal of Neurotrauma·Venkata Ramesh DasariJasti S Rao
Oct 15, 1996·Nucleic Acids Research·B A EldadahA I Faden
Oct 3, 2006·Current Opinion in Anaesthesiology·T Brüssel
May 16, 2000·Critical Care Medicine·M J WhalenP D Adelson
Sep 12, 2000·Neurosurgery·L F Marshall
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Ibolja Cernak
Feb 4, 2014·Future Neurology·Kellie Park, Thomas Biederer
Sep 30, 2004·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Antonio ChiarettiConcezio Di Rocco
Nov 20, 2009·Expert Opinion on Therapeutic Targets·Simone Di Giovanni
Apr 3, 2001·Expert Opinion on Investigational Drugs·A I Maas
Sep 2, 2006·The EMBO Journal·Simone Di GiovanniAlan I Faden
Dec 6, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alex GoraltchoukMolly S Shoichet
May 22, 2001·Best Practice & Research. Clinical Obstetrics & Gynaecology·L H Harris
Oct 13, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·R W KeaneW D Dietrich
Jan 21, 2010·Multiple Sclerosis : Clinical and Laboratory Research·G LovasL D Hudson
Apr 1, 2003·Annals of Neurology·Simone Di GiovanniAlan I Faden
Jul 8, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·Alexandra N GarciaAnthony E Kline
May 19, 2006·Expert Opinion on Therapeutic Targets·Simone Di Giovanni
Nov 4, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Simone Di GiovanniEric P Hoffman
Sep 16, 1999·Annales Françaises D'anesthèsie Et De Rèanimation·V LaudenbachJ M Desmonts

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