PMID: 9438104Jan 23, 1998Paper

Molecular biology of colorectal cancer

Current Problems in Cancer
R GryfeJ Couture

Abstract

Colorectal cancer is a significant cause of morbidity and mortality in Western populations. This cancer develops as a result of the pathologic transformation of normal colonic epithelium to an adenomatous polyp and ultimately an invasive cancer. The multistep progression requires years and possibly decades and is accompanied by a number of recently characterized genetic alterations. Mutations in two classes of genes, tumor-suppressor genes and proto-oncogenes, are thought to impart a proliferative advantage to cells and contribute to development of the malignant phenotype. Inactivating mutations of both copies (alleles) of the adenomatous polyposis coli (APC) gene--a tumor-suppressor gene on chromosome 5q--mark one of the earliest events in colorectal carcinogenesis. Germline mutation of the APC gene and subsequent somatic mutation of the second APC allele cause the inherited familial adenomatous polyposis syndrome. This syndrome is characterized by the presence of hundreds to thousands of colonic adenomatous polyps. If these polyps are left untreated, colorectal cancer develops. Mutation leading to dysregulation of the K-ras protooncogene is also thought to be an early event in colon cancer formation. Conversely, loss of heter...Continue Reading

References

Oct 1, 1976·Science·P C Nowell
Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J Wildenberg, M Meselson
May 1, 1975·The British Journal of Surgery·B Leppard, H J Bussey
Dec 1, 1975·Cancer·T MutoB C Morson
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·Y MiyoshiG Petersen
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M A PeinadoM Perucho
Aug 1, 1992·The Journal of Cell Biology·L ThomasI Stamenkovic
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·R C AllsoppC B Harley
Sep 17, 1992·Nature·S M PowellK W Kinzler
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P ShawJ Costa
Jul 15, 1992·Journal of the National Cancer Institute·R A LotheA L Børresen
Jun 1, 1992·Gut·F Kee, B J Collins
Aug 9, 1991·Science·K W KinzlerD McKechnie
Jan 1, 1992·Diseases of the Colon and Rectum·P A Dean, A M Vernava
Mar 5, 1992·The New England Journal of Medicine·W S AtkinJ Cuzick
Jul 5, 1991·Science·M HollsteinC C Harris
Oct 1, 1991·Digestive Diseases and Sciences·P J WestlakeL R Sutherland
Oct 1, 1991·The British Journal of Surgery·B M StephensonD T Bishop
May 1, 1991·Diseases of the Colon and Rectum·H F VasenH T Lynch
May 1, 1991·Gut·F Kee, B J Collins
Jun 6, 1991·Nature·A J LevineC A Finlay
Jan 1, 1990·Annual Review of Cell Biology·J Massagué
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
May 31, 1990·Nature·C B HarleyC W Greider
Apr 14, 1989·Science·B VogelsteinR White
Mar 1, 1989·European Journal of Cancer & Clinical Oncology·H W VerspagetC B Lamers
Jun 2, 1989·JAMA : the Journal of the American Medical Association·S E KernS R Hamilton
Sep 1, 1988·The New England Journal of Medicine·B VogelsteinJ L Bos
Jun 6, 1987·Lancet·J R JassJ M Northover
Oct 9, 1987·Science·E R FearonB Vogelstein
Jan 1, 1987·Annual Review of Biochemistry·M Barbacid
May 1, 1986·Mayo Clinic Proceedings·A M LotfiL J Melton
Mar 12, 1987·The New England Journal of Medicine·E I TraboulsiS B Welsh

❮ Previous
Next ❯

Citations

Feb 10, 2009·International Journal of Colorectal Disease·Shih-Ching ChangJen-Kou Lin
Jun 22, 2006·Journal of Cancer Research and Clinical Oncology·Mònica ComaladaJulio Gálvez
Aug 30, 2007·Diseases of the Colon and Rectum·Najat MourraSylviane Olschwang
Jul 20, 2007·Cancer Causes & Control : CCC·Matty P WeijenbergPiet A van den Brandt
Jan 19, 2010·Medical Oncology·Dilek YavuzerOya Uygur Bayramicli
May 9, 2000·Cancer Letters·E N ImyanitovM F Lavin
Dec 4, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·G MurilloR G Mehta
Jul 5, 2006·Journal of Pediatric Gastroenterology and Nutrition·Carol A Durno, Steven Gallinger
Nov 8, 2007·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·T A GatcliffeR F Holcombe
Jul 20, 2004·The British Journal of Ophthalmology·R GuthoffA Zettl
Nov 2, 2005·Inflammopharmacology·Reiko AshidaTetsuo Arakawa
Feb 1, 2013·Journal of Biomedical Science·Mohammad Mahdi ForghanifardMohammad Reza Abbaszadegan
May 15, 2007·World Journal of Surgical Oncology·Mary JonesJoseph Mathew
Jan 1, 2008·Hereditary Cancer in Clinical Practice·Tadeusz Debniak, Jan Lubinski
Nov 5, 2003·Annals of Surgical Oncology·Jen-Kou LinAnna Fen-Yau Li
Aug 13, 2013·PLoS Genetics·Valérie MénielAlan R Clarke
Dec 24, 2013·World Journal of Gastroenterology : WJG·Eun Kyung ChoeKyu Joo Park
Jun 30, 2011·Journal of Carcinogenesis·Natalia A IgnatenkoDavid G Besselsen
May 21, 2014·Journal of Clinical Laboratory Analysis·Latha RamireddyWan-Yu Lo
Jul 3, 2015·Oncology Letters·Bin CaiSen Zhang
Mar 18, 2011·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Niccola FunelDaniela Campani
Sep 21, 2000·The Journal of Investigative Dermatology·C Petit-FrèreC F Arlett
Apr 20, 2007·Journal of Molecular Biology·Michael R TallackAndrew C Perkins
Jan 30, 2004·Molecular Carcinogenesis·Natalia A IgnatenkoEugene W Gerner
Mar 27, 2007·Annals of the New York Academy of Sciences·Stanislaw SulkowskiMariola Sulkowska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Adenomatous Polyposis Coli

Adenomatous polyposis coli is a protein encoded by the APC gene and acts as a tumor suppressor. Discover the latest research on adenomatous polyposis coli here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
H YokozakiE Tahara
Gan to kagaku ryoho. Cancer & chemotherapy
Y MikiY Nakamura
Nihon rinsho. Japanese journal of clinical medicine
S Fukushige, A Horii
© 2021 Meta ULC. All rights reserved