PMID: 9443045Jan 27, 1998Paper

Molecular biology of Fanconi anemia

Hematology/oncology Clinics of North America
G M KupferA D D'Andrea

Abstract

Fanconi anemia (FA) is a rare, autosomal recessive disease characterized by multiple congenital abnormalities, bone marrow failure, and cancer susceptibility. Although traditionally described as a classic clinical syndrome, as more is discovered regarding its basic molecular and cell biology, FA is emerging as a true premalignant syndrome. Two of the genes of the five known complementation groups have been cloned, and work to understand their function is underway. Further understanding of these gene products has lent new ideas concerning modes of novel therapy, including gene therapy. The impact of molecular biology on our understanding of basic biology and the clinical care of FA patients is discussed.

References

May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H E BroxmeyerE A Boyse
Aug 1, 1987·American Journal of Medical Genetics·J RosendorffT Jenkins
Sep 1, 1987·Human Genetics·J J GilleH Joenje
Apr 12, 1971·JAMA : the Journal of the American Medical Association·M SwiftE R McDonough
Aug 1, 1984·Cancer Genetics and Cytogenetics·C MecucciH Van den Berghe
May 1, 1983·Cancer Genetics and Cytogenetics·N U PotterF P Li
May 1, 1982·American Journal of Hematology·A D AuerbachH E Broxmeyer
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C C Lau, A B Pardee
Jan 1, 1982·Human Genetics·B DutrillauxM Prieur
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·T YamashitaA D D'Andrea
Aug 1, 1994·The Journal of Clinical Investigation·G M SegalG C Bagby
Nov 1, 1995·Nature Genetics·M Buchwald
Jun 1, 1993·Human Molecular Genetics·R WevrickM Buchwald
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·H Youssoufian
Feb 25, 1994·Science·L ShiA H Greenberg
Apr 1, 1993·The Journal of Clinical Investigation·E A KvittingenR Berger
Jul 1, 1995·Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association·G R SomersD J Venter
Feb 15, 1996·The Journal of Clinical Investigation·H YoussoufianM Buchwald
Jul 18, 1996·The New England Journal of Medicine·J KurtzbergP Rubinstein
Jun 25, 1996·Biochemical and Biophysical Research Communications·J M LiuC E Walsh
Mar 1, 1996·Somatic Cell and Molecular Genetics·P M JakobsM Grompe
Nov 1, 1996·Nature Genetics·UNKNOWN Fanconi anaemia/Breast cancer consortium

❮ Previous
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Citations

Feb 17, 2001·Journal of Biochemical and Biophysical Methods·J Rischewski, R Schneppenheim
Jul 5, 2001·Experimental Hematology·K NakanishiA D D'Andrea
Dec 26, 2001·Experimental Hematology·M A SiddiqueA D D'Andrea
Mar 10, 2001·Molecular Cell·C TimmersM Grompe
May 30, 2001·Trends in Molecular Medicine·M Hoatlin, T Reuter
Oct 19, 1999·Journal of Pediatric Hematology/oncology·K A KnoellR K Malik
Jan 10, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yonggang HeXifeng Wu
Jan 5, 2002·Journal of Periodontology·H NowzariJ Slots
Aug 15, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·R W Herzog, J N Hagstrom
May 14, 2004·International Journal of Paediatric Dentistry·Feyza OtanBurcu Ozkan
Oct 19, 2000·Experimental Cell Research·M Sala-TrepatD Papadopoulo
Oct 23, 1997·American Journal of Human Genetics·H JoenjeF Arwert
Mar 10, 2001·Molecular Cell·I Garcia-HigueraA D D'Andrea
Feb 25, 1999·Radiation Oncology Investigations·P A Kruk, V A Bohr
Mar 20, 2004·Expert Review of Cardiovascular Therapy·Roland W Herzog, Volder R Arruda
Feb 3, 2007·Pediatric Blood & Cancer·Rosa Sherafat-KazemzadehUNKNOWN Fanconi Anemia Comprehensive Care Center

❮ Previous
Next ❯

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