Molecular biology of squamous cell carcinoma of the head and neck.

Journal of Clinical Pathology
B Perez-OrdoñezR C K Jordan

Abstract

Squamous cell carcinoma of the head and neck (HNSCC) is a heterogeneous but largely preventable disease with complex molecular abnormalities. It arises from a premalignant progenitor followed by outgrowth of clonal populations associated with cumulative genetic alterations and phenotypic progression to invasive malignancy. These genetic alterations result in inactivation of multiple tumour suppressor genes and activation of proto-oncogenes, including p16(ink4A), p53, cyclin D1, p14(ARF), FHIT, RASSF1A, epidermal growth factor receptor (EGFR), and Rb. Intramucosal migration and clonal expansion of transformed cells with formation of abnormal genetic fields appear to be responsible for local recurrences and development of second primary tumours.

References

Jun 1, 1987·International Journal of Radiation Oncology, Biology, Physics·T Y ChenD L Driscoll
Feb 1, 1982·Clinical Otolaryngology and Allied Sciences·H HellquistJ Olofsson
Jun 1, 1995·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·P FouretJ L Saint-Guily
Jul 1, 1995·Archives of Otolaryngology--head & Neck Surgery·S D MeredithM E Williams
Feb 16, 1995·The New England Journal of Medicine·J A BrennanD Sidransky
Apr 7, 1998·Cancer·W M LydiattS P Schantz
Jul 17, 1998·Journal of the National Cancer Institute·P P LeongW H Westra
Mar 4, 2000·The Journal of Pathology·S A ShahnavazR C Jordan
Apr 5, 2000·Head & Neck·K T PitmanE N Myers
May 4, 2000·Journal of the National Cancer Institute·M L GillisonD Sidransky
Oct 21, 2000·Molecular Pathology : MP·H K Williams
Apr 12, 2001·The New England Journal of Medicine·J MorkJ Dillner
Apr 26, 2001·The New England Journal of Medicine·J SudbøA Reith
Jul 18, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·S R SchwartzS M Schwartz
Jan 5, 2002·The New England Journal of Medicine·A ForastiereD Sidransky
Feb 28, 2002·Cancer Research·Thomas J BelbinGeoffrey Childs
Jul 27, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·R P HoggF Latif
Sep 5, 2002·International Journal of Cancer. Journal International Du Cancer·Karin AnnertzJohan Wennerberg
Sep 6, 2002·The American Journal of Pathology·Maarten P TaborBoudewijn J M Braakhuis
Nov 16, 2002·The Journal of Pathology·Viola M M van HoutenRuud H Brakenhoff
Nov 26, 2002·Virus Research·Karl Münger, Peter M Howley
Nov 26, 2002·International Journal of Cancer. Journal International Du Cancer·Patrick K HaJoseph A Califano
Dec 4, 2002·The Laryngoscope·Cherie-Ann O NathanFred J Stucker
Jan 2, 2003·Nature Reviews. Cancer·Alan D D'Andrea, Markus Grompe
Jan 15, 2003·Archives of Otolaryngology--head & Neck Surgery·David I KutlerBhuvanesh Singh
Feb 6, 2003·International Journal of Cancer. Journal International Du Cancer·Justine M RitchieThomas H Haugen
Feb 25, 2003·The American Journal of Pathology·Jens P KlussmannPawel G Fuchs

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Citations

Jan 3, 2012·Molecular Biology Reports·Mariângela Torreglosa RuizEny Maria Goloni-Bertollo
May 30, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Kristine E DayEben L Rosenthal
Sep 1, 2009·Journal of Maxillofacial and Oral Surgery·Bhushan V JayadeAswari Sant
Jun 17, 2010·Genes & Development·Tanja van HarnHein te Riele
Jan 31, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Thiago Fonseca-SilvaAndré Luiz Sena Guimarães
Feb 19, 2013·Journal of Translational Medicine·Prabha B MishraMuralidhara Padigaru
May 13, 2009·Head & Neck Oncology·Stijn Fleskens, Piet Slootweg
Jan 11, 2014·The Journal of Craniofacial Surgery·Ana Luíza Laguardia CantaruttiEliete Neves da Silva Guerra
Nov 28, 2013·Pharmacology & Therapeutics·Yu DuJennifer R Grandis
Apr 18, 2014·Indian Journal of Pathology & Microbiology·Soudabeh SargolzaeiMohammad Javad Kharazifard
Oct 15, 2013·Oncogene·Cristina Saiz-LaderaJesús M Paramio
Sep 17, 2014·Oral Oncology·Siavosh TabatabaeifarJens A Sørensen
Jul 18, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jarosław MarkowskiBarbara Jarzab
Dec 29, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Magdy E MahfouzAlfio Ferlito
Nov 11, 2008·Journal of Cancer Research and Clinical Oncology·Silvia S BorkoskyNoriyuki Nagai
May 8, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giulia CourthodGianmauro Numico
May 13, 2008·Expert Review of Anticancer Therapy·Amit M Deshpande, David T Wong
Jan 2, 2016·Oncology Letters·Miguel Reis DE AlmeidaAbel García-García
Apr 12, 2013·Cancer·Janani SivasithamparamAndrea C King
Oct 12, 2013·American Journal of Ophthalmology·Frederick A Jakobiec, Pia R Mendoza
Feb 10, 2012·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S GuihardG Noël
Nov 17, 2010·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Jarosław PaluszczakWanda Baer-Dubowska
Sep 14, 2010·The British Journal of Oral & Maxillofacial Surgery·Kaveh ShakibVukic Soskic
Jul 6, 2010·Biochimica Et Biophysica Acta·Vinitha Richard, M Radhakrishna Pillai
Mar 17, 2010·Oral Oncology·Emily M BenkeW Andrew Yeudall

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