PMID: 8597411Dec 29, 1995Paper

Molecular biology of stress-elicited induction of catecholamine biosynthetic enzymes

Annals of the New York Academy of Sciences
E L SabbanR Kvetnansky

Abstract

Immobilization stress elevates adrenal mRNA for several catecholamine biosynthetic enzymes. Phenylethanolamine N-methyltransferase (PNMT) mRNA is elevated in response to as little as 5 minutes of immobilization, which appears to be a direct consequence of the large rise of glucocorticoids. Tyrosine hydroxylase (TH) mRNA levels are not elevated under these conditions, but are maximally induced by 30 min of a single immobilization. Dopamine beta-hydroxylase (DBH) requires repeated stress for maximal induction. Transcriptional inhibitor actinomycin D prevented the elevation of TH and PNMT mRNA with a single immobilization. Oligonucleotides corresponding to the AP-1 like element in the TH promoter and an important regulatory element in the DBH promoter were used in binding assays with adrenomedullary extracts of rats exposed to stress. The complexes were UV cross-linked and analyzed by gel electrophoresis. The complex bound to the TH AP-1 site contained c-fos and other proteins (including cJun). The complex to the DBH-1 element contained several proteins, probably including fos related proteins but lacked c-fos. Immunoblots found that c-fos is induced in the adrenal medulla near maximally by one hour immobilization and cJun and Jun...Continue Reading

References

Jun 1, 1992·Journal of Neurochemistry·B P FungD M Chikaraishi
Apr 23, 1974·Biochemical and Biophysical Research Communications·R HoeldtkeS Kaufman
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·D M Chuang, E Costa
Apr 1, 1971·The American Journal of Physiology·R KvetnanskýI J Kopin
Jun 21, 1994·Proceedings of the National Academy of Sciences of the United States of America·B NankovaE L Sabban

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Citations

May 13, 2006·Cellular and Molecular Neurobiology·Esther L SabbanRichard Kvetnansky
May 23, 2012·Journal of Molecular Neuroscience : MN·Corey B Smith, Lee E Eiden
Oct 23, 1997·Brain Research. Molecular Brain Research·L SerovaE L Sabban
Aug 10, 2000·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·A B PiekarzewskaG Sender
May 3, 2012·Journal of Cardiovascular Pharmacology·Swapnil V ShewaleMariana Morris
Sep 22, 2009·Canadian Journal of Physiology and Pharmacology·Adriana AdameovaNaranjan S Dhalla
Feb 26, 2008·European Journal of Pharmacology·Nicole A DatsonE Ronald de Kloet
Jul 9, 2004·Annals of the New York Academy of Sciences·Dona L WongRichard Kvetnansky
Jun 23, 2007·Annals of the New York Academy of Sciences·Kunio YuiiMasayoshi Kurachi
Jan 6, 2009·Annals of the New York Academy of Sciences·Dona L WongRichard Kvetnanský
Nov 5, 1997·Annals of the New York Academy of Sciences·R KvetnanskýI Klimes
May 22, 2007·Stress : the International Journal on the Biology of Stress·D L Wong, A W Tank
May 22, 2007·Stress : the International Journal on the Biology of Stress·O KrizanovaL Kubovcakova
Jan 7, 1999·Stress : the International Journal on the Biology of Stress·B B NankovaE L Sabban
May 22, 2002·Molecular Pharmacology·T C TaiDona L Wong
Apr 4, 2009·Physiological Reviews·Richard KvetnanskyMiklos Palkovits
Oct 21, 2004·American Journal of Physiology. Endocrinology and Metabolism·Karen E InouyeMladen Vranic
Jul 21, 1998·Annals of the New York Academy of Sciences·R Kvetnanský, E L Sabban

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