Mar 2, 2016

Molecular Biomarkers of Pancreatic Intraepithelial Neoplasia and Their Implications in Early Diagnosis and Therapeutic Intervention of Pancreatic Cancer

International Journal of Biological Sciences
Junli GuoShaojiang Zheng

Abstract

Lack of early detection and effective interventions is a major reason for the poor prognosis and dismal survival rates for pancreatic cancer. Pancreatic intraepithelial neoplasia (PanIN) is the most common precursor of invasive pancreatic ductal adenocarcinoma (PDAC). Each stage in the progression from PanIN to PDAC is well characterized by multiple significant genetic alterations affecting signaling pathways. Understanding the biological behavior and molecular alterations in the progression from PanIN to PDAC is crucial to the identification of noninvasive biomarkers for early detection and diagnosis and the development of preventive and therapeutic strategies for control of pancreatic cancer progression. This review focuses on molecular biomarkers of PanIN and their important roles in early detection and treatment of pancreatic cancer.

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Mentioned in this Paper

Biological Markers
Biochemical Pathway
Pancreatic Ductal Adenocarcinoma
Pancreatic Carcinoma
Pancreatitis
Pancreatic Intraepithelial Neoplasia (PanIN)
Cancer Progression
Malignant Neoplasm of Pancreas
Cervical Intraepithelial Neoplasia
Tumor Markers

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