Molecular Biomarkers of Response to Antiangiogenic Therapy for Cancer

ISRN Cell Biology
Dan G Duda

Abstract

Antiangiogenic therapy for cancer has gone from an intriguing hypothesis in the 1970s to an accepted treatment approach for many cancer types. It has also become a standard of care for certain eye diseases. Yet, despite the use of molecularly targeted drugs with well defined targets, to date there are no biomarkers to guide the use of antiangiogenic therapy in patients. The mechanisms of action of these drugs are also being debated. This paper discusses some of the emerging biomarker candidates for this type of cancer therapy, which have provided mechanistic insight and might be useful in the future for optimizing cancer treatment.

References

Nov 18, 1971·The New England Journal of Medicine·J Folkman
Mar 10, 2001·Clinical Pharmacology and Therapeutics·UNKNOWN Biomarkers Definitions Working Group.
Aug 6, 2002·Breast Cancer Research and Treatment·Arihiro ShibataHisao Seo
Nov 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Harold F Dvorak
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Jun 5, 2003·Nature Medicine·Napoleone FerraraJennifer LeCouter
Jun 5, 2003·Nature Medicine·Rakesh K Jain
Dec 4, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lee M Ellis
Jan 7, 2004·Nature Reviews. Cancer·Jeffrey W Pollard
Feb 7, 2004·The New England Journal of Medicine·Richard J LevineS Ananth Karumanchi
May 12, 2004·Nature Reviews. Drug Discovery·Napoleone FerraraWilliam Novotny
Jun 3, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·John W ParkDennis J Slamon
Jun 4, 2004·The New England Journal of Medicine·Herbert HurwitzFairooz Kabbinavar
Aug 27, 2004·Nature·Eli PikarskyYinon Ben-Neriah
Oct 1, 2004·The British Journal of Radiology·S M Galbraith
Apr 16, 2005·Neuro-oncology·Daniel J BratErwin G Van Meir
Jul 7, 2005·Journal of the National Cancer Institute·William L InceHartmut Koeppen
Jul 15, 2005·Molecular and Cellular Biochemistry·Madesh Belakavadi, Bharathi P Salimath
Jul 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jerry M Collins
Nov 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Christopher G WillettGregory Y Lauwers
Dec 16, 2005·Nature·Peter Carmeliet
Dec 21, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adrian M JubbHartmut Koeppen
Jan 5, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Suparna Bonthala WedamSandra M Swain
Jan 13, 2006·Nature Clinical Practice. Oncology·Rakesh K JainJay S Loeffler
Dec 15, 2006·The New England Journal of Medicine·Alan SandlerDavid H Johnson
Jan 12, 2007·The New England Journal of Medicine·Robert J MotzerRobert A Figlin
Jan 12, 2007·The New England Journal of Medicine·Bernard EscudierUNKNOWN TARGET Study Group
Mar 31, 2007·Nature Reviews. Drug Discovery·Judah Folkman
Apr 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bruce J GiantonioUNKNOWN Eastern Cooperative Oncology Group Study E3200
Apr 28, 2007·Trends in Molecular Medicine·Dan G DudaRakesh K Jain
May 25, 2007·Nature Reviews. Cancer·Henk M W Verheul, Herbert M Pinedo
Sep 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dan G DudaChristopher G Willett
Nov 21, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael CrumpKathleen I Pritchard
Dec 22, 2007·BMC Complementary and Alternative Medicine·Jennifer RhodeJ Rebecca Liu

❮ Previous
Next ❯

Citations

Jul 3, 2013·Expert Opinion on Investigational Drugs·Matteo MorottiSimone Ferrero
Jun 12, 2016·Pharmacology & Therapeutics·Beverly L FalconBronislaw Pytowski
Aug 21, 2018·Journal of Occupational Health·Anna Machoń-GreckaSławomir Kasperczyk
May 1, 2019·Cancers·Madelaine G van MackelenberghHanneke W M van Laarhoven
Mar 5, 2020·Drug and Chemical Toxicology·Anna Machoń-GreckaSławomir Kasperczyk
Aug 10, 2017·Molecular Medicine Reports·Nunzia CaporarelloCarmelina Daniela Anfuso
Sep 4, 2021·Frontiers in Oncology·Ting YangXinggang Guo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.