Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer

Molecular Cancer Therapeutics
Antonio Jimeno, Manuel Hidalgo

Abstract

The rapidly expanding knowledge of the pathogenesis of pancreatic cancer at the molecular level is providing new targets for disease characterization, early diagnosis, and drug discovery and development. Gene mutation analysis has provided insight on the pathogenesis and progression from preinvasive lesions to invasive cancer. Gene and protein expression profiling has advanced our understanding of pancreatic ductal adenocarcinoma identifying genes that are highly expressed in pancreatic cancers, providing more insight into the clinicopathologic features of pancreatic cancer, and revealing novel features related to the process of tissue invasion by these tumors. The increasing knowledge of the pathway activation profile in pancreatic cancer is yielding new targets but also new markers to select patients and guide and predict therapy efficacy. The discovery of genetic factors of which the presence predisposes pancreatic cancer to successful targeting, such as the association of BRCA2/Fanconi anemia genes defects and sensitivity to mitomycin C, will eventually lead to a more individualized treatment approach. In summary, several decades of intensive research have originated multiple factors or biomarkers that are likely to be help...Continue Reading

References

Jul 5, 1991·Science·M HollsteinC C Harris
Oct 12, 1995·The New England Journal of Medicine·A M GoldsteinW H Clark
Mar 1, 1994·Cancer Metastasis Reviews·R Khosravi-Far, C J Der
Oct 23, 1997·Proceedings of the National Academy of Sciences of the United States of America·M R BootcovS N Breit
Nov 7, 1998·Nature Genetics·K PolyakB Vogelstein
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·S P GygiR Aebersold
Jul 19, 2001·Journal of the National Cancer Institute·A A Adjei
Aug 16, 2001·Proceedings of the National Academy of Sciences of the United States of America·M S NeshatC L Sawyers
Apr 12, 2002·The American Journal of Pathology·Christine A Iacobuzio-DonahueRalph H Hruban
Jun 18, 2002·Hematology/oncology Clinics of North America·Christophe Rosty, Michael Goggins
Oct 26, 2002·Current Problems in Cancer·Theresa Pluth YeoCharles J Yeo
Nov 5, 2002·The American Journal of Pathology·N Tjarda van HeekAnirban Maitra
Feb 6, 2003·Journal of the National Cancer Institute·Stephan A HahnDetlef K Bartsch
Jan 10, 2004·Journal of Gastroenterology·Yuji HinodaSuguru Yonezawa
Jan 17, 2004·Cancer Biology & Therapy·Carmelle D RogersMichael Goggins
Feb 12, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jens KoopmannMichael Goggins
Feb 21, 2004·CA: a Cancer Journal for Clinicians·Ahmedin JemalUNKNOWN American Cancer Society
Apr 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jens KoopmannMichael Goggins
Apr 16, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E Van CutsemD Von Hoff
May 5, 2004·Genome Research·Anirban MaitraAravinda Chakravarti
May 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alan K MeekerAngelo M De Marzo
Jun 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raffit HassanIra Pastan
Jun 30, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Marcia Irene CantoRalph H Hruban
Jul 9, 2004·Pathology, Research and Practice·Udo KellnerMarc Reymond
Oct 12, 2004·Journal of Proteome Research·Mads GrønborgAkhilesh Pandey
Feb 9, 2005·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·X G NiP Zhao
Mar 23, 2005·Nature Methods·Chanjuan ShiJames R Eshleman
Jul 7, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Evanthia GalanisUNKNOWN North Central Cancer Treatment Group
Jul 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michael Goggins

❮ Previous
Next ❯

Citations

Feb 9, 2013·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Xiao-Yu KeDong-Liang Yang
Sep 1, 2007·Current Opinion in Gastroenterology·Tobias Grote, Craig D Logsdon
Dec 24, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Taro OkazakiDonghui Li
Nov 21, 2007·Annals of Surgical Oncology·Tetsuro SasadaArimichi Takabayashi
Jan 1, 2009·OncoTargets and Therapy·Emiliano CalvoEnrique Grande
Oct 3, 2013·International Journal of Molecular Sciences·Antonio GnoniNicola Silvestris
Mar 19, 2009·Experimental & Molecular Medicine·Young Bin HongInsoo Bae
Aug 13, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bao-sheng WangYi Zhao
Oct 1, 2013·Cell Biochemistry and Biophysics·Haleh Akhavan-Niaki, Ali Akbar Samadani
Apr 13, 2007·Expert Review of Anticancer Therapy·J-Matthias Löhr
Sep 24, 2015·Expert Review of Molecular Diagnostics·Aoife S Crawley, Richard J O'Kennedy
Feb 13, 2009·Expert Review of Gastroenterology & Hepatology·Christian GemmelJürgen F Riemann
Sep 1, 2009·Expert Opinion on Medical Diagnostics·Cristiana Pistol TanaseSimona Olimpia Dima
Nov 14, 2012·Biochimica Et Biophysica Acta·Yuqing ZhangMin Li
Apr 3, 2008·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Jan-Bart M KoorstraAnirban Maitra
Sep 1, 2007·Proteomics. Clinical Applications·Mark Aspinall-O'Dea, Eithne Costello
Mar 24, 2009·Cancer Science·Takuya EgamiMasao Tanaka
Mar 30, 2011·Cancer Science·Tadashi KayashimaMasao Tanaka
Nov 20, 2009·Cancer Science·Jia HuangYao-zong Yuan
Feb 5, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guo-Hui SunJing Yang
Feb 28, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yehua ShenZhiqiang Meng
Jun 6, 2009·Molecular Oncology·Aik Choon TanManuel Hidalgo
Sep 25, 2014·BioMed Research International·Ingrid GarajováElisa Giovannetti
Sep 19, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jeremy C WallentineMegan S Lim
Oct 24, 2007·Cancer Investigation·Jeffrey M Skolnik, Peter C Adamson
Nov 28, 2017·Abdominal Radiology·Priya BhosaleEric Tamm

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Related Papers

Best Practice & Research. Clinical Gastroenterology
Anirban MaitraRalph H Hruban
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
G GarceaD P Berry
Expert Opinion on Therapeutic Targets
Giuseppe ToniniDaniele Santini
© 2022 Meta ULC. All rights reserved