Molecular carriers of acquired inheritance: absence of evidence is not evidence of absence

Environmental Epigenetics
Junchao ShiQi Chen

Abstract

In utero exposure to environmental endocrine disruptors can cause transgenerational effects in the males of subsequent generations. DNA methylation (5 mC) was suggested, but being challenged as the molecular carrier of such epigenetic information. In a recent study, Schusteret al.show a changed small RNA profile changed in the sperm of F3 generation after F0in uterovinclozolin exposure, suggesting additional transgenerational epigenetic carriers for endocrine disruptor effects, other than DNA methylation.

References

Jun 4, 2005·Science·Matthew D AnwayMichael K Skinner
Feb 4, 2010·Nature Reviews. Genetics·Peter W Laird
Oct 12, 2010·PloS One·Carlos Guerrero-BosagnaMichael K Skinner
Feb 24, 2012·Nature Reviews. Molecular Cell Biology·Constance Alabert, Anja Groth
Mar 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Eric de WaalJohn R McCarrey
Mar 13, 2013·Cell Research·Seungil RoWei Yan
Apr 15, 2014·Nature Neuroscience·Katharina GappIsabelle M Mansuy
Apr 25, 2015·Cell Research·Fernando R BalestraPierre Gönczy
Nov 21, 2015·Nature Reviews. Endocrinology·Michael K Skinner
Dec 15, 2015·Scientific Reports·Valérie GrandjeanMinoo Rassoulzadegan
Dec 26, 2015·Developmental Cell·Jeremy M SheaOliver J Rando

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Methods Mentioned

BETA
methylation profiling

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.