Molecular changes in detrained & retrained adult jaw muscle

European Journal of Orthodontics
Anna OdmanMark P Lewis


A hypofunctional masticatory system was developed in 21-day-old male rats by feeding them a soft diet for 27 weeks. Retraining of a parallel group for 6 weeks was achieved by switching back to a hard diet after 21 weeks. A control group was fed a hard diet for 27 weeks. At the end of the experimental period, the expression levels of the myosin heavy chain isoform genes MYH 1 and 2 (fast), 3 (embryonic) and 7 (slow) in the deep masseter were compared using qRT-PCR analysis. The gene expressions of MYH 3 and MYH 7 were significantly higher in the rehabilitation group compared with the normal and hypofunctional group, but no significant differences were found in regards to the gene expression of MYH 1 and 2. Retraining made it possible for the slow (MYH 7) isoform levels to adapt to the increased mechanical load. The increased level of embryonic (MYH 3) isoform could be due to the need of creation of new MYH isoforms.


Jan 10, 2019·Acta Odontologica Scandinavica·Anna OdmanStavros Kiliaridis


Oct 1, 1991·Acta Physiologica Scandinavica·B M HatherG A Dudley
Sep 1, 1991·Journal of Dental Research·Stavros Kiliaridis, P Kälebo
May 1, 1983·Journal of Dental Research·W R ProffitW L Nixon
Aug 1, 1994·Journal of Applied Physiology·S Schiaffino, C Reggiani
Mar 1, 1994·Journal of Applied Physiology·R S StaronR S Hikida
Feb 1, 1993·Journal of Applied Physiology·G R AdamsG A Dudley
May 1, 1996·Journal of Applied Physiology·V J CaiozzoK M Baldwin
Apr 1, 1997·International Journal of Oral and Maxillofacial Surgery·Nigel P Hunt, S J Cunningham
Feb 9, 2000·European Journal of Orthodontics·P C BeningtonNigel P Hunt
Nov 12, 2003·Journal of Muscle Research and Cell Motility·Geoffrey Goldspink
Jul 24, 2007·Archives of Oral Biology·George S AbedRobert J Hinton

Related Concepts

Polymerase Chain Reaction Analysis
Gene Expression
Entire Masseter
Myosin Heavy Chains
Protein Isoforms
Bmyo protein, rat

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