Molecular changes in detrained & retrained adult jaw muscle

European Journal of Orthodontics
Anna OdmanMark P Lewis

Abstract

A hypofunctional masticatory system was developed in 21-day-old male rats by feeding them a soft diet for 27 weeks. Retraining of a parallel group for 6 weeks was achieved by switching back to a hard diet after 21 weeks. A control group was fed a hard diet for 27 weeks. At the end of the experimental period, the expression levels of the myosin heavy chain isoform genes MYH 1 and 2 (fast), 3 (embryonic) and 7 (slow) in the deep masseter were compared using qRT-PCR analysis. The gene expressions of MYH 3 and MYH 7 were significantly higher in the rehabilitation group compared with the normal and hypofunctional group, but no significant differences were found in regards to the gene expression of MYH 1 and 2. Retraining made it possible for the slow (MYH 7) isoform levels to adapt to the increased mechanical load. The increased level of embryonic (MYH 3) isoform could be due to the need of creation of new MYH isoforms.

References

Jan 10, 2019·Acta Odontologica Scandinavica·Anna OdmanStavros Kiliaridis

Citations

Oct 1, 1991·Acta Physiologica Scandinavica·B M HatherG A Dudley
Sep 1, 1991·Journal of Dental Research·Stavros Kiliaridis, P Kälebo
May 1, 1983·Journal of Dental Research·W R ProffitW L Nixon
Aug 1, 1994·Journal of Applied Physiology·S Schiaffino, C Reggiani
Mar 1, 1994·Journal of Applied Physiology·R S StaronR S Hikida
Feb 1, 1993·Journal of Applied Physiology·G R AdamsG A Dudley
May 1, 1996·Journal of Applied Physiology·V J CaiozzoK M Baldwin
Apr 1, 1997·International Journal of Oral and Maxillofacial Surgery·Nigel P Hunt, S J Cunningham
Feb 9, 2000·European Journal of Orthodontics·P C BeningtonNigel P Hunt
Nov 12, 2003·Journal of Muscle Research and Cell Motility·Geoffrey Goldspink
Jul 24, 2007·Archives of Oral Biology·George S AbedRobert J Hinton

Related Concepts

Embryo
Jaw
Diet
Polymerase Chain Reaction Analysis
Gene Expression
Entire Masseter
Myosin Heavy Chains
Protein Isoforms
Ingestion
Bmyo protein, rat

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.