Molecular characterisation and epidemiological investigation of an outbreak of blaOXA-181 carbapenemase-producing isolates of Klebsiella pneumoniae in South Africa

South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
Rachael JacobsonColleen Bamford

Abstract

Klebsiella pneumoniae is an opportunistic pathogen often associated with nosocomial infections. A suspected outbreak of K. pneumoniae isolates, exhibiting reduced susceptibility to carbapenem antibiotics, was detected during the month of May 2012 among patients admitted to a haematology unit of a tertiary academic hospital in Cape Town, South Africa (SA). An investigation was done to determine possible epidemiological links between the case patients and to describe the mechanisms of carbapenem resistance of these bacterial isolates. Relevant demographic, clinical and laboratory information was extracted from hospital records and an observational review of infection prevention and control practices in the affected unit was performed. Antimicrobial susceptibility testing including phenotypic testing and genotypic detection of the most commonly described carbapenemase genes was done. The phylogenetic relationship of all isolates containing the blaOXA-181 carbapenemase gene was determined by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing. Polymerase chain reaction analysis identified a total of seven blaOXA-181-positive, carbapenem-resistant K. pneumoniae isolates obtained from seven patients, all from a sin...Continue Reading

Citations

Aug 12, 2016·Journal of Clinical Microbiology·Jolene R BowersPaul Keim
Nov 15, 2019·Clinical Microbiology Reviews·Johann D D PitoutYasufumi Matsumura
Mar 4, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·O PerovicUNKNOWN for GERMS-SA
May 7, 2020·Open Forum Infectious Diseases·Appiah-Korang LabiJorgen A L Kurtzhals
Oct 20, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Dale AnnearSharlene Govender
Dec 18, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Jessica L FraserVictor J Del Rio Vilas
Nov 10, 2021·Annals of the New York Academy of Sciences·Suzan Mohammed RaghebJohn Osei Sekyere

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