Molecular characteristics and potential therapeutic targets in Merkel cell carcinoma

Journal of Clinical Pathology
Shakuntala H MauzoPhyu P Aung

Abstract

Merkel cell carcinoma (MCC) is an aggressive neuroendocrine skin tumour occurring preferentially in elderly and immunosuppressed individuals. Multiple studies have provided insight into the molecular alterations of MCC, leading to the design of several ongoing clinical trials testing chemotherapy, targeted therapy and immunotherapy in patients with recurrent or metastatic disease. The results of some of these studies are available, whereas others are eagerly awaited and will likely shed light on the understanding of MCC biology and potentially improve the clinical outcomes of patients with this rare disease.

References

Feb 1, 1985·The American Journal of Surgical Pathology·R K Sibley, D Dahl
Jan 1, 1972·Archives of Dermatology·C Toker
Aug 1, 1995·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·M L HaagN A Fenske
Dec 1, 1995·Experimental Dermatology·F Fantini, O Johansson
May 1, 1997·Journal of the American Academy of Dermatology·K KrasagakisC E Orfanos
Oct 10, 1998·The British Journal of Dermatology·D TsurutaM Ishii
Oct 24, 1998·The New England Journal of Medicine·E J Lunder, R S Stern
Dec 28, 1999·Transplantation·I Penn, M R First
Jun 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P T TaiJ Gilchrist
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·M Van GeleF Speleman
Apr 21, 2001·Annals of Surgical Oncology·H Medina-FrancoS W Beenken
Feb 21, 2002·Lancet·Eric A EngelsRobert W Miller
Aug 7, 2002·Antisense & Nucleic Acid Drug Development·Richard J KlasaStanley R Frankel
Aug 15, 2002·Transplantation Proceedings·Joseph F BuellE S Woodle
Jan 29, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Zdenek HalataKlaus I Bauman
Feb 26, 2004·Seminars in Oncology·Nevin MurrayFrank V Fossella
Feb 27, 2004·Journal of Cutaneous Pathology·Ryan T MottMichael B Morgan
Dec 21, 2004·Journal of Cutaneous Pathology·Tammie FerringerJohn S Metcalf
Dec 22, 2004·Journal of Surgical Oncology·Nicole C Hodgson
Apr 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Peter J AllenDaniel G Coit
Jul 21, 2005·The British Journal of Dermatology·M WordaP Wolf
Sep 17, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·E AceboJ L Díaz-Pérez
Feb 25, 2006·The Journal of Investigative Dermatology·Roland HoubenJuergen C Becker
Aug 19, 2007·The Journal of Investigative Dermatology·Bianca Lemos, Paul Nghiem
Sep 22, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Monalisa SurSalem Alowami
Jan 19, 2008·Science·Huichen FengPatrick S Moore
Feb 19, 2008·Journal of the American Academy of Dermatology·Michelle HeathPaul Nghiem
Jul 18, 2008·The Journal of Investigative Dermatology·Jürgen C BeckerDavid Schrama
Sep 18, 2008·Cancer·Aleodor A AndeaKlaus J Busam
Mar 25, 2009·American Journal of Clinical Oncology·Manisha H ShahKi Y Chung
Jun 6, 2009·International Journal of Cancer. Journal International Du Cancer·Masahiro ShudaYuan Chang
Jun 6, 2009·International Journal of Cancer. Journal International Du Cancer·Yanis L TolstovPatrick S Moore
Jun 19, 2009·Journal of the National Cancer Institute·Harri SihtoHeikki Joensuu
Sep 15, 2009·PLoS Pathogens·Diana V PastranaChristopher B Buck

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