Molecular characteristics of breast cancer according to clinicopathological factors

Molecular and Clinical Oncology
Joanna Huszno, Zofia Kolosza

Abstract

The purpose of the present study was to evaluate the correlation between molecular factors such as BRCA1 DNA repair associated (BRCA1), checkpoint kinase 2 (CHEK2) and nucleotide binding oligomerization domain containing 2 (NOD2) gene mutations and clinicopathological factors in patients with breast cancer (BC). Prognostic factors were analyzed in BC patients with confirmed BRCA1 (n=73), CHEK2 (n=51) and NOD2 (n=31) mutations. The control group was selected from BC patients without mutations (n=392). The BRCA-associated cancer cases were significantly more often triple negative compared with sporadic cancer (62% vs. 14%; P=0.0001). Luminal B HER2-positive and HER2-positive non-luminal subtypes were observed more often in the control group (33 and 17%). The luminal A subtype was detected in 53% of CHEK2 mutation carriers and 45% of NOD2 mutation carriers. A lower histological grade was observed significantly more often in patients with CHEK2 mutations in comparison with the control group (88 vs. 69%; P=0.003). Lymph nodes without metastases were reported more frequently in NOD2 mutation carriers (74 vs. 54%; P=0.038), in BRCA1 mutations (73 vs. 54%; P=0.004) and, although not significantly, in CHEK2 mutation carriers (69 vs. 54%...Continue Reading

References

Oct 9, 2004·International Journal of Cancer. Journal International Du Cancer·Outi KilpivaaraHeli Nevanlinna
Jan 25, 2005·Breast Cancer Research and Treatment·Tomasz HuzarskiJan Lubinski
Mar 15, 2005·American Journal of Clinical Pathology·Mehrdad NadjiAzorides R Morales
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Oct 3, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·G H de BockJan G M Klijn
Apr 13, 2007·Breast Cancer Research : BCR·Annegien BroeksLaura J Van 't Veer
Jan 1, 2006·Hereditary Cancer in Clinical Practice·Hanna JaniszewskaRyszard Laskowski
Jun 28, 2011·Breast Cancer Research and Treatment·Pawel DomagalaWenancjusz Domagala
Jul 23, 2011·Breast Disease·Beth N PeshkinClaudine Isaacs
Sep 8, 2012·Biologics : Targets & Therapy·Chad J Creighton
May 8, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laxmi Silwal-PanditAnita Langerød
Aug 13, 2014·World Journal of Clinical Oncology·Ozlem Yersal, Sabri Barutca
Jul 22, 2015·Breast Care·Michael GnantNadia Harbeck
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E SenkusESMO Guidelines Committee
Feb 19, 2016·Breast Cancer Research and Treatment·D G EvansA Howell
Apr 22, 2016·Hereditary Cancer in Clinical Practice·Melissa C SoutheyTú Nguyen-Dumont
May 27, 2017·Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists·Joanna HusznoElżbieta Nowara
May 30, 2017·Breast Cancer : Targets and Therapy·Panagiotis Apostolou, Ioannis Papasotiriou
Jun 15, 2017·Breast Care·Michael HubalekHannes Müller
Jul 6, 2017·The Lancet Oncology·Brian O'SullivanMary Gospodarowicz
Jul 15, 2017·Integrative Cancer Science and Therapeutics·Inês Godet, Daniele M Gilkes
Feb 9, 2019·Journal, Genetic Engineering & Biotechnology·Halla Mohamed RagabHebatAllah Mohamed Shaaban

Related Concepts

Malignant Neoplasm of Breast
Lymph Nodes
Neoplasm Metastasis
Nucleotides
Phosphotransferases
Lumin
Associated Disease
Subtype (Attribute)
Luminal Region
Gene Mutation

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