Molecular characteristics of differentiated-type gastric carcinoma with distinct mucin phenotype: LI-cadherin is associated with intestinal phenotype

Pathology International
Junichi MotoshitaWataru Yasui

Abstract

Gastric carcinomas (GC) are classified into four phenotypes on the basis of the mucin expression profile: G type (gastric or foveolar phenotype), I type (intestinal phenotype), GI type (intestinal and gastric mixed phenotype) and N type (neither gastric nor intestinal phenotype). Immunohistochemistry was used to examine the expression of epidermal growth factor receptor (EGFR), E-cadherin, liver-intestine (LI)-cadherin, CD44v9 and p53 and correlation of these molecules with mucin phenotype and tumor stage was evaluated. Overexpression of EGFR and LI-cadherin, reduced expression of E-cadherin and abnormal expression of p53 were observed more frequently in advanced GC than in early GC. Among I-type GC, overexpression of EGFR and reduced expression of E-cadherin were observed more frequently in advanced tumors than in early tumors. Among G-type GC, reduced expression of E-cadherin was significantly associated with advanced tumors. With respect to the relationship between mucin phenotype and expression of cancer-related molecules, overexpression of LI-cadherin was observed more frequently in I-type (12/25, 48.0%) than in G-type (1/14, 7.1%) GC. I-type GC tended to express LI-cadherin more frequently than GI-type GC. These results p...Continue Reading

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Jul 27, 2005·Virchows Archiv : an International Journal of Pathology·Reiko ItoWataru Yasui

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Citations

Apr 9, 2009·Pathology International·Jung Wook HuhJae Kyoon Joo
Apr 20, 2014·World Journal of Gastroenterology : WJG·Lin-Hai YanQiang Xiao
Aug 21, 2012·American Journal of Clinical Pathology·Nicole C PanarelliYao-Tseng Chen
Jan 31, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Katsuya MorimatsuYoshinao Oda
Mar 28, 2020·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Nair LopesLeonor David

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