Molecular characteristics of extended spectrum beta-lactamases in Escherichia coli and Klebsiella pneumoniae and the prevalence of qnr in Extended spectrum beta-lactamase isolates in a tertiary care hospital in Korea.

Yonsei Medical Journal
Myeong Hee KimJin Tae Suh

Abstract

Extended spectrum beta-lactamases (ESBLs) are cephalosporinases that confer resistance to a wide variety of oxyimino cephalosporins and create serious therapeutic problems. In addition, the quinolone resistance qnr genes are becoming increasingly prevalent in clinical isolates, some of which also produce ESBL. This study was designed to evaluate the occurrence and genotypic distribution of ESBL producing Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) as well as the prevalence and distribution of qnr genes in ESBL-producing isolates in a tertiary care hospital in Korea. We tested a total of 111 ESBL-producing isolates of E. coli and K. pneumoniae, which were collected at Kyung Hee Medical Center from November 2006 to June 2008. ESBL production was determined by the Clinical and Laboratory Standards Institute (CLSI) ESBL confirmatory test. The cefotaxime and ceftazidime resistance of the ESBL-producers were transferred to azide-resistant E. coli J53 by conjugation. The presence and identity of ESBL and qnr genes were determined by polymerase chain reaction (PCR) and nucleotide sequencing. The prevalence of ESBLs was 17.7% (297/1,680) of E. coli and 26.5% (240/904) of K. pneumoniae in our hospital during the ...Continue Reading

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Citations

Nov 6, 2014·Jundishapur Journal of Microbiology·Fereshteh RaeiMohammad Mehdi Feizabadi
Feb 13, 2016·Jundishapur Journal of Microbiology·Elnaz Harifi MoodMahboubeh Naderi Nasab
Mar 9, 2011·International Journal of Antimicrobial Agents·Shio-Shin Jean, Po-Ren Hsueh
Nov 20, 2012·Journal of Medical Microbiology·Kesavaram PadmavathySikhamani Rajasekaran
Oct 26, 2018·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Hyukmin LeeKwang Jun Lee
Nov 26, 2020·Postgraduate Medical Journal·Rajanbir Kaur, Rajinder Kaur

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Methods Mentioned

BETA
PCR
electrophoresis

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