Molecular characterization and chromosomal localization of DRT (EPHT3): a developmentally regulated human protein-tyrosine kinase gene of the EPH family

Human Molecular Genetics
N IkegakiD E Pleasure

Abstract

By screening a human fetal brain cDNA expression library using a monoclonal antiphosphotyrosine antibody and by 5' RACE procedures, we have isolated overlapping cDNAs encoding a receptor-type tyrosine kinase belonging to the EPH family, DRT (Developmentally Regulated EPH-related Tyrosine kinase gene). The DRT gene is expressed in three different size transcripts (i.e. 4, 5 and 11 kb). DRT transcripts are expressed in human brain and several other tissues, including heart, lung, kidney, placenta, pancreas, liver and skeletal muscle, but the 11 kb DRT transcript is preferentially expressed in fetal brain. Steady-state levels of DRT mRNA in several tissues, including brain, heart, lung and kidney, are greater in the midterm fetus than those in the adult. DRT transcripts are detectable at low levels in a human teratocarcinoma cell line (NTera-2), but its expression is greatly increased after the NTera-2 cells are induced to become postmitotic neurons (NTera-2N) by retinoic acid treatment. These data suggest that DRT plays a part in human neurogenesis. A large number of tumor cell lines derived from neuroectoderm express DRT transcripts, including 12 neuroblastomas, two medulloblastomas, one primitive neuroectodermal tumor and six s...Continue Reading

Citations

Mar 19, 2004·Pathology Oncology Research : POR·Qinghua WuJahn M Nesland
Apr 21, 2007·Science in China. Series C, Life Sciences·Liang XiaDaCheng He
May 12, 1998·Pharmacology & Therapeutics·R Zhou
Feb 25, 2010·Nature Reviews. Cancer·Elena B Pasquale
Dec 20, 2000·Journal of Biosciences·R BhandariS Visweswariah
Jan 22, 2005·Journal of Cancer Research and Clinical Oncology·Wei-Zhong WuKang-Da Liu
Apr 24, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Anna-Carina Weiss, Andreas Kispert
Sep 21, 2002·Microscopy Research and Technique·Masaru Nakamoto, Andrew D Bergemann
Dec 2, 2004·Nature Reviews. Cancer·Hirofumi Arakawa
Apr 9, 2005·Cell Death and Differentiation·H Arakawa
Jul 24, 2001·Medical and Pediatric Oncology·X X TangN Ikegaki

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