Molecular characterization and clinical epidemiology of HCV in District Dir (Lower), Pakistan

Virusdisease
Sami UllahAnshu Babbar

Abstract

With about 200 million infections globally, Hepatitis C virus (HCV) infection is a major global health threat. The relative prevalence of hepatitis and HCV genotypes/subtypes varies among different geographic regions. Therefore, the present study was conducted to determine the prevalence of hepatitis C and HCV genotypes/subtypes in District Dir (Lower), Pakistan. Blood samples from HCV positive patients were genotyped through multiplex PCR using specific primers for HCV core region. A structured questionnaire was used to obtain information from the patients and data was statistically analyzed for different epidemiological parameters. The molecular evaluation results suggested the prevalence of genotype 3 in this study. The frequency of hepatitis C was found higher in males (P < 0.01). Present study suggests injections received at local clinics as a highly significant mode of HCV transmission to these patients (P < 0.002). These findings might be helpful for clinicians and related health care personnel to assess status of this important disease and highlight the need for more detailed evaluation of this devastating disease in order to frame better treatment strategies.

References

Mar 1, 1993·Journal of Hepatology·N TakadaT Date
Jan 1, 1993·Journal of Hepatology·J H HoofnagleM Shindo
Jul 14, 2001·Revista Do Instituto De Medicina Tropical De São Paulo·F M TenganA A Barone
Oct 19, 2001·Journal of Clinical Gastroenterology·M Aslam, J Aslam
Feb 5, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Beat HelblingUNKNOWN Investigators of the Swiss Association for the Study of the Liver
Mar 1, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·John G McHutchisonUNKNOWN International Hepatitis Interventional Therapy Group
Oct 31, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jay H Hoofnagle
Apr 4, 2008·Tropical Medicine & International Health : TM & IH·Uzma R KhanJuanita Hatcher
Apr 19, 2008·Journal of Digestive Diseases·Muhammad IdreesMuhammad Khalid
Oct 7, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Syed Asad AliSten H Vermund
Dec 5, 2009·World Journal of Gastroenterology : WJG·Yasir WaheedIshtiaq Qadri
May 5, 2010·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Sadia ButtShazia Rafique
Sep 8, 2010·World Journal of Gastroenterology : WJG·Waqar AhmadSajida Hassan
Apr 20, 2016·BMC Infectious Diseases·Amina GulIjaz Ali

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
DNA Taq
Genotyping

Software Mentioned

Statistical package for social sciences ( SPPS )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.