Molecular characterization and expression pattern of the porcine STARS, a striated muscle-specific expressed gene

Biochemical Genetics
Y B PengBang Liu

Abstract

STARS (striated muscle activator of Rho signaling) promotes the nuclear localization of MRTFs and mediates SRF transcription, which provides a potential muscle-specific mechanism for linking changes in the actin cytoskeleton structure with muscle gene expression. In this study, the full-length cDNA of the porcine STARS was cloned. The open reading frame of this gene contains 1,155 bp and encodes a protein of 384 amino acids, which is 79, 73, and 77% identical with human, mouse, and rat STARS genes, respectively. RT-PCR revealed that STARS is specifically expressed in heart and skeletal muscles. STARS is also distinctly different in different muscle developmental stages. The result indicates that its expression increased gradually from 33 dpc (days postcoitum) to postnatal muscles, and peaked 28 days postnatal. The porcine STARS was mapped to SSC4p13 using the somatic cell hybrid panel and the radiation hybrid panel IMpRH (LOD score 11.98). The data show that STARS is closely linked to marker SW871. A T/G single nucleotide polymorphism in the coding sequence, detected as Bsh1236I PCR-RFLP, displays allele frequency differences in six pig breeds.

References

May 1, 1995·Developmental Dynamics : an Official Publication of the American Association of Anatomists·L LefaucheurG S Butler-Browne
Feb 1, 1997·Computer Applications in the Biosciences : CABIOS·C ChevaletM SanCristobal-Gaudy
Jan 19, 1999·Annual Review of Cell and Developmental Biology·A Schmidt, M N Hall
Aug 10, 2000·Trends in Cell Biology·C C Gregorio, P B Antin
Sep 12, 2000·Bioinformatics·D MilanJ Gellin
May 2, 2002·The Journal of Biological Chemistry·Akiko AraiEric N Olson
Mar 31, 2005·Molecular and Cellular Biology·Koichiro KuwaharaEric N Olson
Apr 7, 2007·The Journal of Clinical Investigation·Koichiro KuwaharaEric N Olson

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Citations

Mar 26, 2013·Pflügers Archiv : European journal of physiology·Séverine LamonKristian Vissing
Feb 22, 2014·Pflügers Archiv : European journal of physiology·Séverine LamonAaron P Russell
May 31, 2013·American Journal of Physiology. Cell Physiology·Marita A Wallace, Aaron P Russell

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