Molecular characterization and expression analysis of stanniocalcin-1 in turbot (Scophthalmus maximus)

General and Comparative Endocrinology
Jihye ShinYoung Chang Sohn

Abstract

Stanniocalcin-1 (STC-1) is an anti-hypercalcemic hormone that is produced by the corpuscles of Stannius (CS) in the teleost. The hormone is a homodimeric glycoprotein involved in the calcium and phosphate regulation in both teleost fish and mammals. In the present study, we have cloned and characterized a full-length cDNA of STC-1 from the turbot (Scophthalmus maximus) CS and examined its expression pattern in various tissues. The turbot STC cDNA (1,246 nucleotides) encodes a putative preprohormone of 248 amino acids (aa) with a signal peptide of 18 aa and a pro-sequence peptide of 14 aa followed by a mature protein of 216 aa. The deduced aa sequence of turbot STC-1 shows the highest sequence identity (86.3%) with that of European flounder STC-1 among the fish and mammalian STC-1. The aa sequence of turbot STC-1 showed moderate sequence identity with those of salmoniforms (chum salmon and rainbow trout), cypriniforms (zebrafish), ancient fish (gar and bowfin), and humans (43.7-66.9%), respectively, whereas it showed less identity with those of zebrafish and human STC-2 (23.8-25.4%). RT-PCR analysis revealed that the turbot STC-1 gene is expressed in the CS, pituitary, brain, kidney, liver, heart, muscle, and gonad. In a transie...Continue Reading

References

Oct 1, 1991·General and Comparative Endocrinology·R G HanssenS E Wendelaar Bonga
Aug 11, 1995·Molecular and Cellular Endocrinology·K YamashitaH Kawauchi
Nov 29, 1996·Molecular and Cellular Endocrinology·A C ChangR R Reddel
Sep 2, 1998·Molecular and Cellular Endocrinology·A C Chang, R R Reddel
Oct 1, 1998·Biochemical and Biophysical Research Communications·K IshibashiM Imai
Sep 27, 2001·The Journal of Endocrinology·C R McCuddenG F Wagner
Dec 31, 2003·General and Comparative Endocrinology·Yutaka Amemiya, John H Youson
Oct 13, 2004·Peptides·Yuji Yoshiko, Jane E Aubin

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Citations

Apr 5, 2012·ISRN Endocrinology·Timothy D J RichardsGraham F Wagner
Aug 29, 2009·BMC Structural Biology·Daniel M TrindadeJörg Kobarg
May 12, 2011·Integrative and Comparative Biology·Graeme J Roch, Nancy M Sherwood
Dec 20, 2008·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Jihye Shin, Young Chang Sohn
Nov 26, 2011·Molecular and Cellular Endocrinology·B H Y YeungChris K C Wong
Dec 17, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Deng-Yu TsengPung-Pung Hwang
Dec 14, 2018·Pflügers Archiv : European journal of physiology·Tiziano Verri, Andreas Werner

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