Molecular characterization of a novel human hybrid-type receptor that binds the alpha2-macroglobulin receptor-associated protein.

The Journal of Biological Chemistry
L JacobsenC M Petersen

Abstract

The 39-40-kDa receptor-associated protein (RAP) binds to the members of the low density lipoprotein receptor gene family and functions as a specialized endoplasmic reticulum/Golgi chaperone. Using RAP affinity chromatography, we have purified a novel approximately 250-kDa brain protein and isolated the corresponding cDNA. The gene, designated SORL1, maps to chromosome 11q 23/24 and encodes a 2214-residue type 1 receptor containing a furin cleavage site immediately preceding the N terminus determined in the purified protein. The receptor, designated sorLA-1, has a short cytoplasmic tail containing a tyrosine-based internalization signal and a large external part containing (from the N-terminal): 1) a segment homologous to domains in the yeast vacuolar protein sorting 10 protein, Vps10p, that binds carboxypeptidase Y, 2) five tandemly arranged YWTD repeats and a cluster of 11 class A repeats characteristic of the low density lipoprotein receptor gene family receptors, and 3) six tandemly arranged fibronectin type III repeats also found in certain neural adhesion proteins. sorLA-1 may therefore be classified as a hybrid receptor. Northern blotting revealed specific mRNA transcripts in brain, spinal cord, and testis but not in seve...Continue Reading

References

Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·G BuA L Schwartz
Nov 1, 1991·Journal of Neuroscience Research·J T PrinceW B Stallcup
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K F JohnsonS Kornfeld
Oct 23, 1987·Science·E Ruoslahti, M D Pierschbacher
Jun 1, 1983·European Journal of Biochemistry·G von Heijne
Jul 1, 1995·Journal of the American Society of Nephrology : JASN·M G FarquharR A Orlando
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·N L DalyR Smith
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·W J Strittmatter, A D Roses
Apr 1, 1995·Current Opinion in Lipidology·H Jingami, T Yamamoto
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·A SaitoM G Farquhar
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·C P TensenE Vreugdenhil

❮ Previous
Next ❯

Citations

Dec 22, 1999·Biochemical and Biophysical Research Communications·G HermeyI Hermans-Borgmeyer
Sep 29, 2011·Experimental Brain Research·Timo Wagner, Claus U Pietrzik
Dec 21, 2000·Current Atherosclerosis Reports·W J SchneiderM Drexler
Feb 3, 2012·Molecular Neurobiology·Lone Tjener Pallesen, Christian Bjerggaard Vaegter
Apr 28, 2004·Advanced Drug Delivery Reviews·Nancy S Chung, Kishor M Wasan
May 17, 2005·Methods : a Companion to Methods in Enzymology·Tarek M BajariWolfgang Johann Schneider
Aug 7, 1998·Atherosclerosis·T P Hiltunen, S Ylä-Herttuala
Jun 12, 1998·Brain Research. Brain Research Reviews·U BeffertJ Poirier
Mar 5, 1999·Brain Research. Molecular Brain Research·I Hermans-BorgmeyerC Schaller
Aug 26, 1998·Trends in Cell Biology·G Bu, A L Schwartz
Mar 10, 2001·Trends in Cardiovascular Medicine·G Bu, M P Marzolo
Jun 2, 2005·Nature Reviews. Cancer·Dario Neri, Roy Bicknell
Nov 13, 2008·Nature Reviews. Neuroscience·Thomas E WillnowAnders Nykjaer
Jan 6, 2009·Nature Structural & Molecular Biology·Esben M QuistgaardSøren S Thirup
May 16, 2013·Translational Psychiatry·C ReitzUNKNOWN Alzheimer's Disease Genetics Consortium (ADGC)
Dec 15, 2010·The Journal of Biological Chemistry·Jeremy H HerskowitzJames J Lah
Jul 8, 2008·The Journal of Biological Chemistry·Stefan K NilssonGunilla Olivecrona
Sep 3, 1998·DNA and Cell Biology·T KanakiY Saito
May 25, 2012·Molecular Biology of the Cell·Jeremy H HerskowitzJames J Lah
Feb 2, 1999·The EMBO Journal·C Munck PetersenP Madsen
Dec 3, 2010·Current Opinion in Lipidology·Thomas E WillnowAnders Nykjaer
Jul 25, 2007·Molecular and Cellular Biology·Morten S NielsenClaus M Petersen
Apr 14, 2010·Molecular and Cellular Biology·Juliane ReicheThomas E Willnow
Jun 5, 2002·Annual Review of Biochemistry·Joachim Herz, Hans H Bock
Aug 17, 1999·Annual Review of Nutrition·M M HussainA Bakillah
Jul 12, 2008·The Journal of Clinical Investigation·Meizi JiangYasushi Saito
Mar 17, 1999·The Journal of Clinical Investigation·D M HoltzmanS M Paul
Oct 26, 2006·Molecular Neurodegeneration·G William RebeckEdwin J Weeber
Jan 11, 2011·Molecular Brain·Yun-wu ZhangHuaxi Xu
Nov 3, 2011·PloS One·Christiane ReitzRichard Mayeux

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.