Molecular characterization of a novel hypovirus from the plant pathogenic fungus Fusarium graminearum

Virology
Pengfei LiLihua Guo

Abstract

A novel mycovirus, termed Fusarium graminearum Hypovirus 2 (FgHV2/JS16), isolated from a plant pathogenic fungus, Fusarium graminearum strain JS16, was molecularly and biologically characterized. The genome of FgHV2/JS16 is 12,800 nucleotides (nts) long, excluding the poly (A) tail. This genome has only one large putative open reading frame, which encodes a polyprotein containing three normal functional domains, papain-like protease, RNA-dependent RNA polymerase, RNA helicase, and a novel domain with homologous bacterial SMC (structural maintenance of chromosomes) chromosome segregation proteins. A defective RNA segment that is 4553-nts long, excluding the poly (A) tail, was also detected in strain JS16. The polyprotein shared significant aa identities with Cryphonectria hypovirus 1 (CHV1) (16.8%) and CHV2 (16.2%). Phylogenetic analyses based on multiple alignments of the polyprotein clearly divided the members of Hypoviridae into two major groups, suggesting that FgHV2/JS16 was a novel hypovirus of a newly proposed genus-Alphahypovirus-composed of the members of Group 1, including CHV1, CHV2, FgHV1 and Sclerotinia sclerotiorum hypovirus 2. FgHV2/JS16 was shown to be associated with hypovirulence phenotypes according to compari...Continue Reading

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Citations

May 6, 2016·International Journal of Molecular Sciences·Luan WangLihua Guo
Nov 22, 2016·International Journal of Molecular Sciences·Shuangchao WangLihua Guo
May 7, 2016·Scientific Reports·Yayun HuoWeimin Li
Aug 10, 2019·Phytopathology·Maria D D García-PedrajasJosé Sebastián Dambolena
Sep 13, 2019·Virology Journal·Chenchen LiuXiliang Jiang
Feb 15, 2020·Archives of Virology·Qin LiMinghong Wang
Jun 6, 2018·Frontiers in Microbiology·Leonardo VelascoCarlos López-Herrera
Feb 11, 2020·Frontiers in Microbiology·Almudena Torres-TrenasEncarnación Pérez-Artés
Jun 4, 2019·Frontiers in Microbiology·Huan LiLiying Sun
Aug 6, 2019·Frontiers in Cellular and Infection Microbiology·Pengfei LiLihua Guo
May 11, 2020·Virus Genes·Abu Bakar Siddique

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