Molecular characterization of a wild poliovirus type 3 epidemic in The Netherlands (1992 and 1993).

Journal of Clinical Microbiology
M N MuldersM P Koopmans

Abstract

An outbreak of poliomyelitis due to wild poliovirus type 3 (PV3) occurred in an unvaccinated community in The Netherlands between September 1992 and February 1993. The outbreak involved 71 patients. The aim of this study was to characterize the virus at the molecular level and to analyze the molecular evolution of the epidemic virus. Molecular analysis was carried out by sequencing the VP1/2A junction region (150 nucleotides) of 50 PV3 strains isolated in association with this outbreak and the entire VP1 gene of 14 strains. In addition, the sequence of the VP1/2A junction region of strains from geographical regions endemic for PV3 (Egypt, India, and Central Asia) was analyzed and compared with the nucleotide sequence of the epidemic strain from The Netherlands. The earliest isolate was obtained from river water sampled 3 weeks before diagnosis of the first poliomyelitis patient and was found by VP1/2A sequence analysis to be genetically identical to the strain isolated from the first patient. Sequence divergence among the strains from the epidemic in The Netherlands was less than 2%. The closest genetic similarity (97.3%) was found with an Indian isolate (New Delhi, December 1991), indicating the likely source of the virus. A m...Continue Reading

References

Jul 1, 1986·The Journal of General Virology·P D MinorJ P Icenogle
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Dec 1, 1995·The Journal of General Virology·A HuovilainenT Hovi

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Citations

Apr 29, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Tarik Derrough, Alexandra Salekeen
Aug 22, 2003·Reviews in Medical Virology·Walter R DowdleDavid J Wood
Nov 2, 2019·Journal of Medical Virology·Yongjiang QianHongxing Shen
Apr 23, 2017·Applied and Environmental Microbiology·Kimberley S M BenschopErwin Duizer
Sep 13, 2005·Annual Review of Microbiology·Olen M KewMark A Pallansch
Apr 19, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mingbo SunQihan Li
Oct 9, 1999·Clinical Microbiology Reviews·M Arens
Feb 1, 1997·Applied and Environmental Microbiology·M A DrebotS H Lee

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