PMID: 9423883Jan 10, 1998Paper

Molecular characterization of an outer membrane protein of Actinobacillus actinomycetemcomitans belonging to the OmpA family

Infection and Immunity
P A WhiteB Henderson

Abstract

The major outer membrane protein (OMP) of Actinobacillus actinomycetemcomitans is an OmpA homolog that demonstrates electrophoretic heat modifiability. The gene encoding this protein was isolated from a genomic library of A. actinomycetemcomitans NCTC 9710 by immunoscreening with serum from a patient with localized juvenile periodontitis. Expression of the cloned gene in Escherichia coli and subsequent Western blot analysis revealed a protein with an approximate molecular mass of 34 kDa. The amino acid sequence predicted from the cloned gene demonstrated that the mature protein had a molecular mass of 34,911 Da and significant identity to members of the OmpA family of proteins. We have named the major OMP of A. actinomycetemcomitans Omp34, and its corresponding gene has been named omp34.

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Citations

Jul 11, 2000·Microbiology and Immunology·H HaraK Fukui
Oct 7, 2003·Annual Review of Microbiology·Brian HendersonMichael Wilson
Aug 26, 2006·Periodontology 2000·Daniel H FineHelen C Schreiner
Dec 6, 2002·Journal of Medical Microbiology·Brian HendersonJohn M Ward
Jul 15, 2017·Journal of Proteome Research·Arancha Llama-PalaciosMariano Sanz

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