Molecular characterization of Blastocystis species in Oregon identifies multiple subtypes.

Parasitology Research
Christopher M WhippsMichael L Kent

Abstract

The association of Blastocystis species infections with gastrointestinal symptoms in humans is clouded by the variable presentation of disease and multiple lineages of the parasite that can infect humans and other animals. It has long been suspected that certain subtypes of Blastocystis may be more or less pathogenic, be restricted to certain hosts, or have limits to their geographic distribution. In the state of Oregon, USA, Blastocystis spp. are the most commonly encountered parasites in fecal specimens submitted for diagnostic evaluation, yet the diversity of subtypes is unknown. In this study, fecal samples were collected from individuals experiencing symptoms associated with blastocystosis and analyzed by polymerase chain reaction for presence of the parasite and DNA sequenced for subtyping. Five of 19 individuals tested positive for the parasite, all of which were also positive by previous ova and parasitology examination. DNA sequencing of the small subunit ribosomal DNA and elongation factor 1 alpha gene followed by phylogenetic subtyping identified five unique subtypes, representing Blastocystis subtypes 1, 2, 3, 4, and 8. No symptoms were consistently associated with presence or absence of infection, although abdomina...Continue Reading

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Citations

Jan 1, 2014·PloS One·Awatif M AbdulsalamJohari Surin
Feb 23, 2011·Parasitology Research·Dionigia MeloniEric Viscogliosi
Feb 17, 2015·The Journal of Parasitology·William D HelenbrookChristopher M Whipps
Nov 26, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·C Rune StensvoldC Graham Clark
Jul 29, 2016·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Alexandra M GoeJames F X Wellehan
Aug 29, 2014·Therapeutic Advances in Infectious Disease·Ivan WawrzyniakHicham El Alaoui
Nov 30, 2018·Parasitology Research·Jenny G MaloneyMonica Santin
Jul 31, 2019·Parasites & Vectors·Paula Andrea JiménezJuan David Ramírez
Nov 22, 2019·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Davood ShakerShirzad Gholami
Dec 3, 2020·International Journal of Environmental Research and Public Health·Noppon PoprukDuangdao Palasuwan
Apr 30, 2021·Acta Parasitologica·William D Helenbrook, Christopher M Whipps

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