Molecular characterization of carbapenem-resistant Pseudomonas aeruginosa strains isolated from patients with urinary tract infections in Southern Poland

Diagnostic Microbiology and Infectious Disease
M PobiegaJ Wojkowska-Mach

Abstract

Due to the clinical threat posed by multidrug-resistant (MDR) Pseudomonas aeruginosa and importance of virulence factors produced in infection, 21 carbapenem-resistant P. aeruginosa were analyzed. 42.8% metallo-beta-lactamases-positive strains were identified. 85.7% of strains were meropenem resistant. 14.2% of strains were MDR; 38%, extensively drug-resistant (XDR). ExoY was present in all strains; exoT, in 95.2%; exoS, in 90.5%; exoU, in 47.6%. Eight XDR strains were typed using multilocus sequence typing: 4 as ST235, 2 as ST260, 2 as ST654 and ST234. MDR P. aeruginosa were isolated from hospitalized patients and among those from the community. Our study demonstrates the serious clinical issues posed by MDR P. aeruginosa and underscores the need for new treatment.

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Citations

Mar 23, 2017·Revista Da Sociedade Brasileira De Medicina Tropical·Wirlaine Glauce MacielSimone Simionatto
Dec 21, 2017·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Selina Y L Holbrook, Sylvie Garneau-Tsodikova
Jan 30, 2016·Antimicrobial Agents and Chemotherapy·L F MatasejeJ D Pitout
May 17, 2019·International Journal of Environmental Health Research·Asma Bel Hadj AhmedAbdennaceur Hassen
Oct 13, 2018·BMC Infectious Diseases·Kaidi TellingIrja Lutsar
Dec 15, 2018·Polish Journal of Microbiology·Mikołaj MichnoWładysław Sułowicz
Feb 15, 2021·Microbiological Research·Gertrudis Horna, Joaquim Ruiz

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