PMID: 8587390Jan 1, 1995Paper

Molecular characterization of endothelin receptors and the effect of insulin on their expression in retinal microvascular pericytes

Journal of Cardiovascular Pharmacology
D McDonaldU Chakravarthy

Abstract

Microvascular pericytes contain predominantly endothelin A (ET(A))-like binding sites and also a smaller number of ETB binding sites. In this study we verified the expression of both receptors in these cells. We then examined the effect of insulin, a potent mediator of vasodilatation, on the expression of these receptors in pericytes by Northern hybridization. Northern hybridization studies showed that ET(A) mRNA levels were not influenced by exposure to insulin (1 x 10(-7) M). By contrast, ETB receptor mRNA, which was minimal under basal conditions, was significantly increased by 4 h after exposure to insulin.

Citations

Apr 27, 1999·Progress in Retinal and Eye Research·U Chakravarthy, T A Gardiner
May 22, 1998·Journal of Cardiovascular Pharmacology·R L HopfnerV Gopalakrishnan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.