Molecular characterization of Epstein-Barr virus and oncoprotein expression in nasopharyngeal carcinoma in Korea

Head & Neck
Yoon Kyung JeonChul Woo Kim

Abstract

We evaluated the characteristics of nasopharyngeal carcinoma in Korea, including its clinical, pathologic, and molecular features, especially emphasizing on the EBV strains involved, latent membrane protein 1 (LMP1) expression, and the alterations of matrix metalloproteinase 9 (MMP9) and E-cadherin expression. METHODS.: The presence of EBV was evaluated by EBER in situ hybridization, and the expression of LMP1, MMP9, and E-cadherin by immunohistochemistry. The characterization of EBV type and LMP1 variant was performed by PCR. EBER was detected in 55 of 57 cases (96%) of nonkeratinizing carcinoma (NKC) and undifferentiated carcinoma, but in only four of nine cases (44%) of squamous cell carcinoma (SCC). EBER positivity was much higher in the group with nodal metastases (p =.003). The predominant strain of EBV infection was type A (81%) and a 30-bp deletion LMP1 variant (77%). All EBER-positive SCCs were infected with EBV type A. LMP1 expression was detected in 36 of 59 (61%) patients with latent EBV infection and MMP9 in 41 of these 59 (69%). LMP1 positivity was much higher among the patients aged 50 years and younger. MMP9 expression was associated with LMP1 expression (p =.008), and nodal and distant metastasis (p =.019, p =....Continue Reading

References

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Oct 1, 1994·The Journal of General Virology·W E MillerN Raab-Traub
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·T YoshizakiJ S Pagano

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Citations

Apr 5, 2005·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·S RiveraP Maingon
Jun 10, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xue ChenYa Cao
Nov 19, 2019·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Mohammad Hadi Karbalaie NiyaAlireza Tabibzadeh

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