Molecular characterization of equine infectious anaemia virus from a major outbreak in southeastern France

Transboundary and Emerging Diseases
D GaudaireA Hans

Abstract

In 2009, a major outbreak of equine infectious anaemia (EIA) was reported in the south-east of France. This outbreak affected three premises located in the Var region where the index case, a 10-year-old mare that exhibited clinical signs consistent with EIA, occurred at a riding school. Overall, more than 250 horses were tested for EIAV (equine infectious anaemia virus) antibodies, using agar gel immunodiffusion test, and 16 horses were positive in three different holdings. Epidemiological survey confirmed that the three premises were related through the purchase/sale of horses and the use of shared or nearby pastures. Molecular characterization of viruses was performed by sequencing the full gag gene sequence (1,400 bp) of the proviral DNAs retrieved from the spleen of infected animals collected post-mortem. Phylogenetic analysis confirmed epidemiological data from the field, as viruses isolated from the three premises were clustering together suggesting a common origin whereas some premises were 50 km apart. Moreover, viruses characterized during this outbreak are different from European strains described so far, underlying the high genetic diversity of EIAV in Europe.

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Citations

May 13, 2018·Archives of Virology·Andreia Elisa CursinoErna Geessien Kroon
Feb 9, 2018·Oncotarget·Hua-Nan WangJian-Guo Dong
Jul 23, 2019·Veterinary World·Abdulmohsen Abdullah Alnaeem, Maged Gomaa Hemida
Dec 8, 2020·Transboundary and Emerging Diseases·Andreia Elisa CursinoErna Geessien Kroon
Apr 3, 2021·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·César I Romo-SáenzRicardo Gomez-Flores
Apr 17, 2021·BMC Veterinary Research·Diana LupulovicAymeric Hans

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