Molecular characterization of genotype 2 and 4 hepatitis C virus isolates in French blood donors.

Journal of Medical Virology
Jean-François CantaloubePhilippe De Micco

Abstract

The subtype distribution of 142 genotype 2 and 97 genotype 4 hepatitis C virus (HCV) isolates from the sera of 1,319 volunteer blood donors in France was determined by gene sequencing and by phylogenetic analysis of the NS5B region and E1 envelope. Findings underlined a wide range of subtypes in both genotypes, that is, 20 in HCV-2 and 11 in HCV-4. Eighteen of these 31 subtypes had not been defined previously. Some subtypes, that is, 2a, 2b, 2c, 2i, 2k, 4a, and 4d, showed numerous strains while subtypes in donors from West Africa or Central Africa showed an endemic profile with only a few strains. A Bayesian coalescence approach was used to estimate the demographic history of each HCV subtype. The estimated mean dates of the most recent common ancestors (MRCA) were 1,889 (confidence interval (CI), 1,842-1,930) for HCV-2a, 1,886 (CI, 1,843-1,921) for HCV-2b, 1,791 (CI, 1,699-1,848) for HCV-2c, 1,846 (CI, 1,803-1,878) for HCV-2i, 1,911 (CI, 1,879-1,937) for HCV-4a, and 1,957 (CI, 1,943-1,967) for HCV-4d. The period of spread for subtype 2b, 2c, and 2i was between 1900 and 1960 whereas rapid exponential spread for subtype 2a, 4a, and 4d occurred in the 1960s. The inferred histories of population growth indicated that transmission ...Continue Reading

References

Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G InchauspeA M Prince
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·Q L ChooP J Barr
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·H TokitaM Mayumi
Sep 1, 1994·The Journal of General Virology·L Z XuD Kremsdorf
May 1, 1994·The Journal of General Virology·D QuC Trépo
Jul 1, 1993·The Journal of Infectious Diseases·T KinoshitaS Mishiro
Sep 1, 1996·The Journal of General Virology·A RuggieriM Rapicetta
Sep 1, 1996·Journal of Clinical Microbiology·L StuyverG Maertens
Aug 19, 2000·The Journal of Infectious Diseases·S C RayD L Thomas
Jun 26, 2001·Science·O G PybusP H Harvey
Mar 22, 2002·Journal of Virology·Olga KalininaLars O Magnius
Oct 29, 2002·The Journal of Infectious Diseases·Alexandra CochranePeter Simmonds
Jul 2, 2003·Antiviral Research·Jean Michel Pawlotsky
Jul 21, 2004·Briefings in Bioinformatics·Sudhir KumarMasatoshi Nei
Aug 21, 2004·The Journal of Infectious Diseases·Tatsunori NakanoOliver G Pybus
Sep 21, 2004·Bioinformatics·Carla KuikenRussell Richardson
Dec 18, 2004·The Journal of General Virology·Florence NicotJacques Izopet
Feb 11, 2005·Molecular Biology and Evolution·A J DrummondO G Pybus
Feb 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Markus ReiserGerhard G Steinmann
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KaplanKyong-Mi Chang
Aug 6, 2005·Journal of Clinical Microbiology·Jean-François CantaloubeXavier de Lamballerie
Sep 9, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Peter SimmondsAnders Widell
Dec 20, 2005·The Journal of General Virology·Tatsunori NakanoOliver G Pybus
Apr 14, 2006·Journal of Virology·Jannick VerbeeckMarc Van Ranst
Jun 8, 2006·Journal of Clinical Microbiology·Jean-François CantaloubePhilippe de Micco

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Citations

May 28, 2013·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Lin GuLing Lu
Mar 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stéphane ChevaliezJean-Michel Pawlotsky
Sep 28, 2010·Journal of Medical Virology·Mette Brandt EriksenUNKNOWN DANHEP Group
Sep 5, 2014·Journal of Medical Virology·Siew-Lin NguiMary E Ramsay
Jul 31, 2012·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Natalie CletonChantal Reusken
Jun 29, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Nadia MarascioAnna Rita Ciccaglione
Apr 20, 2014·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Livia Maria Gonçalves Rossi, Paula Rahal
Feb 19, 2010·Journal of Medical Virology·Jean-François CantaloubePhilippe de Micco
Dec 12, 2018·World Journal of Hepatology·Maléki AssihJacques Simpore

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