Molecular characterization of human group C rotavirus genes 6, 7 and 9

The Journal of General Virology
V L JamesI N Clarke


Genes 6, 7 and 9 of human group C rotavirus 'Bristol' strain, encoding non-structural proteins (NSP) 3, 1 and 2, respectively, were cloned and sequenced. Human group C rotavirus genome segment 6 is 1350 bp and contains a single ORF of 1231 nucleotides (encoding 402 amino acids). Genome segment 7 is 1270 bp and encodes a protein of 394 amino acids and genome segment 9 is 1037 bp and encodes a 312 amino acid protein. The human group C rotavirus genes 6, 7 and 9 showed 78, 67 and 88% sequence identity, respectively, to the corresponding porcine group C rotavirus genes. The derived protein sequences were compared with those of the porcine 'Cowden' group C and mammalian group A rotavirus strains. The human group C rotavirus NSP1 protein sequence is one amino acid longer than the porcine group C equivalent. In common with group A and porcine group C rotaviruses, the human group C rotavirus NSP1 protein has a zinc finger motif. Human group C rotavirus NSP2 has two hydrophobic heptad repeat regions, a basic, RNA-binding domain and a basic, proline-rich region. Human group C rotavirus NSP3 has both single- and double-stranded RNA-binding domains and several hydrophobic heptad repeat regions, one of which forms a leucine zipper. This wor...Continue Reading


Mar 1, 1992·Journal of Virology·P R LambdenI N Clarke
Mar 1, 1990·Journal of Medical Virology·E O CaulJ C Bridger
Nov 1, 1988·The Journal of Infectious Diseases·R YolkenS Vonderfecht
Jan 1, 1986·The Journal of General Virology·S PedleyM A McCrae
Feb 1, 1987·Journal of Clinical Microbiology·D W BrownT H Flewett
May 1, 1987·Journal of Clinical Microbiology·S NakataJ L Melnick
Dec 29, 1973·Lancet·T H FlewettH Davies
Jan 1, 1984·Virus Research·B L PetrieM K Estes
Oct 1, 1982·Journal of Clinical Microbiology·S M RodgerI H Holmes
Jan 1, 1980·Journal of Steroid Biochemistry·G A PucaV Sica
Mar 1, 1995·Human Molecular Genetics·M HergersbergA Aguzzi
Oct 1, 1994·Journal of Medical Virology·A S GriceI N Clarke
Dec 1, 1994·The Journal of General Virology·L XuM A McCrae
Dec 1, 1994·The Journal of General Virology·E A Palombo, R F Bishop
Jun 1, 1996·Trends in Genetics : TIG·W Hanna-Rose, U Hansen
Jan 1, 1997·Annual Review of Microbiology·R F Ramig
Feb 9, 1999·Lancet·T KrishnanS K Bhattacharya
Jul 1, 1985·Evolution; International Journal of Organic Evolution·Joseph Felsenstein

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