Molecular characterization of human group C rotavirus genes 6, 7 and 9

The Journal of General Virology
V L JamesI N Clarke

Abstract

Genes 6, 7 and 9 of human group C rotavirus 'Bristol' strain, encoding non-structural proteins (NSP) 3, 1 and 2, respectively, were cloned and sequenced. Human group C rotavirus genome segment 6 is 1350 bp and contains a single ORF of 1231 nucleotides (encoding 402 amino acids). Genome segment 7 is 1270 bp and encodes a protein of 394 amino acids and genome segment 9 is 1037 bp and encodes a 312 amino acid protein. The human group C rotavirus genes 6, 7 and 9 showed 78, 67 and 88% sequence identity, respectively, to the corresponding porcine group C rotavirus genes. The derived protein sequences were compared with those of the porcine 'Cowden' group C and mammalian group A rotavirus strains. The human group C rotavirus NSP1 protein sequence is one amino acid longer than the porcine group C equivalent. In common with group A and porcine group C rotaviruses, the human group C rotavirus NSP1 protein has a zinc finger motif. Human group C rotavirus NSP2 has two hydrophobic heptad repeat regions, a basic, RNA-binding domain and a basic, proline-rich region. Human group C rotavirus NSP3 has both single- and double-stranded RNA-binding domains and several hydrophobic heptad repeat regions, one of which forms a leucine zipper. This wor...Continue Reading

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Citations

Aug 24, 2010·Journal of Virological Methods·Omar DarissaGünter Adam
Aug 25, 2015·The Journal of General Virology·Szilvia MartonKrisztián Bányai
Aug 20, 2002·The Journal of General Virology·A C PotgieterA A van Dijk
Aug 13, 2011·The Journal of General Virology·Tohru SuzukiHiroshi Tsunemitsu
Jul 19, 2006·Journal of Medical Virology·Andrej SteyerJozica Marin

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