Molecular Characterization of IMP-1-Producing Enterobacter cloacae Complex Isolates in Tokyo

Antimicrobial Agents and Chemotherapy
Kotaro AokiKazuhiro Tateda

Abstract

Although KPC enzymes are most common among carbapenemases produced by Enterobacter cloacae complex globally, the epidemiology varies from one country to another. While previous studies have suggested that IMP enzymes are most common in Japan, detailed analysis has been scarce thus far. Here, we carried out a molecular epidemiological study and plasmid analysis of IMP-1-producing E. cloacae complex isolates collected from three hospitals in central Tokyo using whole-genome sequencing. Seventy-one isolates were classified into several sequence types (STs), and 49 isolates were identified as Enterobacter hormaechei ST78. Isolates of ST78 were divided into three clades by core-genome single nucleotide polymorphism (SNP)-based phylogenetic analysis. Whereas isolates of clade 3 were isolated from only one hospital, isolates of clade 1 and 2 were identified from multiple hospitals. Ten of 12 clade 1 isolates and 1 of 4 clade 2 isolates carried blaIMP-1 on IncHI2 plasmids, with high similarity of genetic structures. In addition, these plasmids shared backbone structures with IncHI2 plasmids carrying blaIMP reported from other countries of the Asia-Pacific region. All isolates of clade 3 except one carried blaIMP-1 in In1426 on IncW pla...Continue Reading

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Jun 7, 2005·Journal of Microbiological Methods·Alessandra CarattoliE John Threlfall
Dec 17, 2008·Antimicrobial Agents and Chemotherapy·Ying-Tsong ChenShih-Feng Tsai
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Oct 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Michael Richter, Ramon Rosselló-Móra
Feb 1, 2011·Bioinformatics·Mitchell J SullivanScott A Beatson
Aug 10, 2011·BMC Genomics·Nabil-Fareed AlikhanScott A Beatson
Nov 15, 2011·Diagnostic Microbiology and Infectious Disease·Norifumi ShigemotoMotoyuki Sugai
Nov 16, 2011·Antimicrobial Agents and Chemotherapy·Laurent PoirelPatrice Nordmann
Jun 6, 2012·Antimicrobial Agents and Chemotherapy·Hisakazu YanoMitsuo Kaku
May 3, 2013·Journal of Clinical Microbiology·Louis-Patrick HaraouiMark A Miller
Jun 19, 2013·PloS One·Tohru Miyoshi-AkiyamaTeruo Kirikae
Feb 8, 2014·International Journal of Systematic and Evolutionary Microbiology·Mincheol KimJongsik Chun
Apr 12, 2014·PLoS Computational Biology·Remco BouckaertAlexei J Drummond
Apr 29, 2014·Cell·Etienne Maisonneuve, Kenn Gerdes
Apr 30, 2014·Antimicrobial Agents and Chemotherapy·Alessandra CarattoliHenrik Hasman
Jul 25, 2014·Journal of Clinical Microbiology·Hanna E SidjabatDavid L Paterson
Sep 14, 2014·The Journal of Antimicrobial Chemotherapy·R IzdebskiUNKNOWN MOSAR WP2, WP3 and WP5 Study Groups
Feb 13, 2015·PLoS Computational Biology·Xavier Didelot, Daniel J Wilson
Oct 21, 2015·Antimicrobial Agents and Chemotherapy·Alexander M WailanHanna E Sidjabat
Sep 8, 2016·Antimicrobial Agents and Chemotherapy·Nicole StoesserJohann D Pitout
Nov 22, 2016·Bioscience of Microbiota, Food and Health·Yasuhiro TanizawaMasanori Arita
Dec 23, 2016·International Journal of Systematic and Evolutionary Microbiology·Seok-Hwan YoonJongsik Chun
Dec 26, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pranita D TammaPatricia J Simner
Jan 18, 2017·Proceedings of the National Academy of Sciences of the United States of America·Gustavo C CerqueiraWilliam P Hanage
Feb 9, 2017·Antimicrobial Agents and Chemotherapy·Yasufumi MatsumuraJohann D D Pitout
Mar 16, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·N Deborah FriedmanMitchell James Schwaber

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Citations

Mar 18, 2019·The Journal of Antimicrobial Chemotherapy·Yao ZhuSiguo Liu
Aug 3, 2018·Clinical Microbiology Reviews·Sally R PartridgeSlade O Jensen
Jul 20, 2019·Microbiology Resource Announcements·Priyanka BaranwalMasahiro Takeo
Feb 16, 2019·Frontiers in Microbiology·Medini K AnnavajhalaAnne-Catrin Uhlemann
Jul 2, 2021·Japanese Journal of Infectious Diseases·Jayathilake SarangiYoshichika Arakawa

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