Molecular characterization of invasive meningococcal isolates in Burkina Faso as the relative importance of serogroups X and W increases, 2008-2012

BMC Infectious Diseases
Adam RetchlessXin Wang

Abstract

Neisseria meningitidis serogroup A disease in Burkina Faso has greatly decreased following introduction of a meningococcal A conjugate vaccine in 2010, yet other serogroups continue to pose a risk of life-threatening disease. Capsule switching among epidemic-associated serogroup A N. meningitidis strains could allow these lineages to persist despite vaccination. The introduction of new strains at the national or sub-national levels could affect the epidemiology of disease. Isolates collected from invasive meningococcal disease in Burkina Faso between 2008 and 2012 were characterized by serogrouping and molecular typing. Genome sequences from a subset of isolates were used to infer phylogenetic relationships. The ST-5 clonal complex (CC5) was identified only among serogroup A isolates, which were rare after 2010. CC181 and CC11 were the most common clonal complexes after 2010, having serogroup X and W isolates, respectively. Whole-genome phylogenetic analysis showed that the CC181 isolates collected during and after the epidemic of 2010 formed a single clade that was closely related to isolates collected in Niger during 2005 and Burkina Faso during 2007. Geographic population structure was identified among the CC181 isolates, wh...Continue Reading

References

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Citations

Nov 2, 2019·The Journal of Infectious Diseases·Yibayiri Osee SanogoXin Wang
Nov 2, 2019·The Journal of Infectious Diseases·Adam C RetchlessXin Wang
May 28, 2020·The American Journal of Tropical Medicine and Hygiene·Brenda A Kwambana-Adams On Behalf Of The Paediatric Bacterial Meningitis Surveillance Network In West Africa
Jun 3, 2021·The New England Journal of Medicine·Milagritos D TapiaPrasad S Kulkarni
Sep 2, 2021·The Journal of Infectious Diseases·Brenda Anna Kwambana-AdamsJason Mathiu Mwenda

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Datasets Mentioned

BETA
AM421808.1
PRJNA338313

Software Mentioned

BioPython
phyML
SciPy
ClonalFrameML
Mauve Contig Mover
PubMLST
iToL
LSD
XMFA
BLAST

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